A systematic approach to selecting task relevant neurons

Kevin Kahn, Shreya Saxena, Emad N. Eskandar, Nitish Thakor, Marc Schieber, John T. Gale, Bruno Averbeck, Uri Eden, Sridevi V. Sarma

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Since task related neurons cannot be specifically targeted during surgery, a critical decision to make is to select which neurons are task-related when performing data analysis. Including neurons unrelated to the task degrade decoding accuracy and confound neurophysiological results. Traditionally, task-related neurons are selected as those with significant changes in firing rate when a stimulus is applied. However, this assumes that neurons' encoding of stimuli are dominated by their firing rate with little regard to temporal dynamics. New method: This paper proposes a systematic approach for neuron selection, which uses a likelihood ratio test to capture the contribution of stimulus to spiking activity while taking into account task-irrelevant intrinsic dynamics that affect firing rates. This approach is denoted as the model deterioration excluding stimulus (MDES) test. Results: MDES is compared to firing rate selection in four case studies: a simulation, a decoding example, and two neurophysiology examples. Comparison with existing methods: The MDES rankings in the simulation match closely with ideal rankings, while firing rate rankings are skewed by task-irrelevant parameters. For decoding, 95% accuracy is achieved using the top 8 MDES-ranked neurons, while the top 12 firing-rate ranked neurons are needed. In the neurophysiological examples, MDES matches published results when firing rates do encode salient stimulus information, and uncovers oscillatory modulations in task-related neurons that are not captured when neurons are selected using firing rates. Conclusions: These case studies illustrate the importance of accounting for intrinsic dynamics when selecting task-related neurons and following the MDES approach accomplishes that. MDES selects neurons that encode task-related information irrespective of these intrinsic dynamics which can bias firing rate based selection.

Original languageEnglish (US)
Pages (from-to)156-168
Number of pages13
JournalJournal of Neuroscience Methods
Volume245
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

Fingerprint

Neurons
Neurophysiology

Keywords

  • Model based
  • Neuron selection
  • Point processes
  • Task-related neurons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Kahn, K., Saxena, S., Eskandar, E. N., Thakor, N., Schieber, M., Gale, J. T., ... Sarma, S. V. (2015). A systematic approach to selecting task relevant neurons. Journal of Neuroscience Methods, 245, 156-168. https://doi.org/10.1016/j.jneumeth.2015.02.020

A systematic approach to selecting task relevant neurons. / Kahn, Kevin; Saxena, Shreya; Eskandar, Emad N.; Thakor, Nitish; Schieber, Marc; Gale, John T.; Averbeck, Bruno; Eden, Uri; Sarma, Sridevi V.

In: Journal of Neuroscience Methods, Vol. 245, 01.04.2015, p. 156-168.

Research output: Contribution to journalArticle

Kahn, K, Saxena, S, Eskandar, EN, Thakor, N, Schieber, M, Gale, JT, Averbeck, B, Eden, U & Sarma, SV 2015, 'A systematic approach to selecting task relevant neurons', Journal of Neuroscience Methods, vol. 245, pp. 156-168. https://doi.org/10.1016/j.jneumeth.2015.02.020
Kahn, Kevin ; Saxena, Shreya ; Eskandar, Emad N. ; Thakor, Nitish ; Schieber, Marc ; Gale, John T. ; Averbeck, Bruno ; Eden, Uri ; Sarma, Sridevi V. / A systematic approach to selecting task relevant neurons. In: Journal of Neuroscience Methods. 2015 ; Vol. 245. pp. 156-168.
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