A sliding microtubule model incorporating axonemal twist and compatible with three-dimensional ciliary bending.

M. E. Holwill, H. J. Cohen, P. Satir

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

1. Equations are developed to calculate the relative displacements of the doublet microtubules at the tip of a cilium when the microtubules twist about the axis of the organelle. 2. Displacements measured from electron micrographs show asymmetry (or skew) which can be matched quantitatively by the theoretical model with the appropriate selection of twist angle and orientation of the axoneme with respect to the plane of beat. 3. For Elliptio cilia the experimental results are consistent with a planar effective stroke and a recovery stroke involving a three-dimensional bend. The plane of the effective stroke is not normal to a surface containing the central pair of microtubules but contains microtubule 2 to produce the observed skew. 4. This model for the beat also explains the range of orientations of axoneme observed in sections through the metachronal wave.

Original languageEnglish (US)
Pages (from-to)265-280
Number of pages16
JournalJournal of Experimental Biology
Volume78
StatePublished - Feb 1979
Externally publishedYes

Fingerprint

Microtubules
microtubules
sliding
stroke
Axoneme
Cilia
Stroke
cilia
asymmetry
Organelles
organelles
electron
Theoretical Models
electrons
Electrons

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

A sliding microtubule model incorporating axonemal twist and compatible with three-dimensional ciliary bending. / Holwill, M. E.; Cohen, H. J.; Satir, P.

In: Journal of Experimental Biology, Vol. 78, 02.1979, p. 265-280.

Research output: Contribution to journalArticle

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