A single centre experience of treatment outcomes for Helicobacter pylori infection among inner-city children and adolescents

Jubin Mathews, Preeti Malik, Anjali Rai, Juan Lin, Ryung S. Kim, Debra H. Pan

Research output: Contribution to journalArticle

Abstract

Aim: This study assessed treatment outcomes of Helicobacter pylori (H pylori) infection among inner-city children. Methods: This was a retrospective study of patients aged 1-21 years who underwent initial treatment for H pylori infection from 2011 to 2015. We included patients who completed 2 weeks of treatment with documented adequate compliance after H pylori infection was diagnosed. Treatment outcomes were measured based on stool H pylori antigen and/or histology. Results: Of the total 261 patients diagnosed with H pylori, 239 completed the first-line treatment. The regimens used included amoxicillin/clarithromycin/proton pump inhibitor (PPI) in 207/239 patients (86.6%), amoxicillin/metronidazole/PPI in 14/239 patients (5.8%) and other regimens in 18/239 patients (7.5%). H pylori eradication status was tested in 111/207 (53.6%) patients treated with amoxicillin/clarithromycin/PPI, and the eradication was achieved in 84/111(75.7%) patients. The treatment success rates for amoxicillin/metronidazole/PPI and other regimens were 71.4% (5/7) and 63.6% (7/11), respectively. There was no statistical significance of post-treatment stool H pylori antigen results between PPI (n = 31) and no PPI (n = 43) users. Conclusion: The study showed an eradication rate of 75.7% with the regimen amoxicillin/clarithromycin/PPI suggesting significant antibiotic resistance in our population. The use of PPI did not influence post-treatment stool H pylori antigen results.

Original languageEnglish (US)
JournalActa Paediatrica, International Journal of Paediatrics
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • Helicobacter pylori infection
  • children
  • treatment outcome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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