A single-center experience of endoscopic ultrasonography for enlarged pancreas on computed tomography

Sammy Ho, Robert J. Bonasera, Bonnie J. Pollack, James Grendell, Martin Feuerman, Frank Gress

Research output: Contribution to journalArticle

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Abstract

Background & Aims: The clinical significance of "fullness" or enlargement of the pancreas (FP/EP) is not well established. The objective of this study was to report our experience with endoscopic ultrasonography (EUS) in evaluating patients referred for FP/EP found on computed tomography (CT). Methods: Patients referred to our center for EUS evaluation of FP/EP between January 1998 and December 2003 were studied. Patient demographics, clinical history, endoscopic findings, and follow-up were recorded. Multivariate analysis was used to identify predictors of pancreatic malignancy. Results: A total of 50 patients: 46% (23/50) male, mean age 59 years (range, 18-90) made up our studied population. EUS demonstrated normal findings in 42% (21/50), prominent ventral anlage (embryologic variant) in 14% (7/50), and chronic pancreatitis in 22% (11/50). In 22% (11/50), a suspicious mass was noted and fine-needle aspiration (FNA) was performed. Cytology revealed chronic inflammation in 7 patients, while adenocarcinoma was found in the remaining 4. Median follow-up was 27 months, and the diagnosis did not change in any of the 50 patients. There were no procedure-related complications. After multivariant regression analysis, the factors that were statistically associated with malignancy were a CA19-9 level >300 (P = .0002) and weight loss (P < .006). Conclusions: The majority of patients presenting with FP/EP had benign disease, but 8% had pancreatic cancer. Elevated CA19-9 and weight loss were predictive of pancreatic malignancy. EUS and EUS-FNA are safe and accurate diagnostic tests and can play an important role in evaluating patients with FP/EP.

Original languageEnglish (US)
Pages (from-to)98-103
Number of pages6
JournalClinical Gastroenterology and Hepatology
Volume4
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

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Endosonography
Pancreas
Tomography
Fine Needle Biopsy
Weight Loss
Neoplasms
Chronic Pancreatitis
Pancreatic Neoplasms
Routine Diagnostic Tests
Cell Biology
Adenocarcinoma
Multivariate Analysis
Regression Analysis
Demography
Inflammation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A single-center experience of endoscopic ultrasonography for enlarged pancreas on computed tomography. / Ho, Sammy; Bonasera, Robert J.; Pollack, Bonnie J.; Grendell, James; Feuerman, Martin; Gress, Frank.

In: Clinical Gastroenterology and Hepatology, Vol. 4, No. 1, 01.2006, p. 98-103.

Research output: Contribution to journalArticle

Ho, Sammy ; Bonasera, Robert J. ; Pollack, Bonnie J. ; Grendell, James ; Feuerman, Martin ; Gress, Frank. / A single-center experience of endoscopic ultrasonography for enlarged pancreas on computed tomography. In: Clinical Gastroenterology and Hepatology. 2006 ; Vol. 4, No. 1. pp. 98-103.
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