A ROS rheostat for cell fate regulation

Maria Maryanovich, Atan Gross

Research output: Contribution to journalReview article

84 Scopus citations

Abstract

Cellular reactive oxygen species (ROS) are tightly regulated to prevent tissue damage. ROS also help to monitor different cell fates, suggesting that a 'ROS rheostat' exists in cells. It is well established that ROS are crucial for stem cell biology; in this review, we discuss how mitochondrial ROS influence hematopoietic cell fates. We also examine the importance in this process of BID and other BCL-2 family members, many of which have been implicated in regulating cell fates by modulating mitochondrial integrity/activity and cell cycle progression in the hematopoietic lineage. Based on this knowledge, we propose that selected BCL-2 proteins coordinate mitochondria and nuclear activities via ROS to enable 'synchronized' cell fate decisions.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalTrends in Cell Biology
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

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Keywords

  • ATM
  • BID
  • Cell cycle regulation
  • Hematopoietic lineage
  • Mitochondria
  • Reactive oxygen species
  • Stem cell biology

ASJC Scopus subject areas

  • Cell Biology

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