A review of paroxysmal hemicranias, SUNCT syndrome and other short-lasting headaches with autonomic feature, including new cases

Peter J. Goadsby, Richard B. Lipton

Research output: Contribution to journalArticle

631 Citations (Scopus)

Abstract

The short-lasting primary headache syndromes may be conveniently divided into those exhibiting marked autonomic activation and those without autonomic activation. The former group comprise chronic and episodic paroxysmal hemicrania, short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT syndrome) and cluster headache. These headache syndromes are compared with other short-lasting headache disorders, such as hypnic headache, and persistent headache with milder autonomic features such as hemicrania continua. Cluster headache is included with the shorter-lasting headaches to attempt a nosological analysis of these syndromes. The paroxysmal hemicranias are characterized by frequent short-lasting attacks of unilateral pain usually in the orbital supraorbital or temporal region that typically last minutes. The attack frequency usually ranges from 5 to 40 attacks per day. The pain is severe and associated with autonomic symptoms such as conjunctival injection, lacrimation, nasal congestion, rhinorrhoea, ptosis or eyelid oedema. Almost all reported cases respond to treatment with indomethacin, but respond poorly to other treatments including other nonsteroidal anti-inflammatory drugs. A recent case study demonstrated the release of both trigeminal and parasympathetic neuropeptides during a bout of pain in the same pattern previously described in cluster headache. The SUNCT syndrome is a distinctive rare condition characterized by less severe pain but marked autonomic activation during attacks. Consistent with previous reports, the present case of SUNCT syndrome was intractable to therapy. The similarites of these syndromes suggests a considerable shared pathophysiology. It is suggested that the syndromes are sufficiently well established for inclusion in the International Headache Society Classification system and that trigeminal-autonomic cephalalgias should be classified as a group together. A proposed re-classification is presented.

Original languageEnglish (US)
Pages (from-to)193-209
Number of pages17
JournalBrain
Volume120
Issue number1
DOIs
StatePublished - Jan 1997

Fingerprint

SUNCT Syndrome
Headache
Cluster Headache
Headache Disorders
Paroxysmal Hemicrania
Pain
Trigeminal Autonomic Cephalalgias
Primary Headache Disorders
Blepharoptosis
Injections
Temporal Lobe
Neuropeptides
Nose
Indomethacin
Edema
Anti-Inflammatory Agents
Therapeutics
Pharmaceutical Preparations

Keywords

  • Chronic paroxysmal hemicrania
  • Cluster headache
  • Hemicrania continua
  • Hypnic headache
  • Parasympathetic

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A review of paroxysmal hemicranias, SUNCT syndrome and other short-lasting headaches with autonomic feature, including new cases. / Goadsby, Peter J.; Lipton, Richard B.

In: Brain, Vol. 120, No. 1, 01.1997, p. 193-209.

Research output: Contribution to journalArticle

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