Abstract
The host factors that contribute to the increased susceptibility of preterm neonates to invasive candidiasis have not been fully identified. In addition, there has been a lack of suitable models to study this problem. We show that rat pups, similar to premature neonates, display increased susceptibility to experimental Candida albicans infection. Further, we find that both C. albicans and Candida parapsilosis lipase disruptant mutants exhibit decreased virulence in rat pups, demonstrating the utility of the model to evaluate the impact of specific genes in disease pathogenesis. Our findings highlight the contribution of lipases to the virulence of C. albicans and C. parapsilosis and provide a new system to study the increased susceptibility of neonates to Candida infections.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-178 |
| Number of pages | 10 |
| Journal | Mycopathologia |
| Volume | 172 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2011 |
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Keywords
- Candida
- Infection model
- Lipases
- Rat
ASJC Scopus subject areas
- Plant Science
- Agronomy and Crop Science
- Applied Microbiology and Biotechnology
- Microbiology
- veterinary (miscalleneous)
Cite this
A Rat Model of Neonatal Candidiasis Demonstrates the Importance of Lipases as Virulence Factors for Candida albicans and Candida parapsilosis. / Trofa, David; Soghier, Lamia; Long, Christina; Nosanchuk, Joshua D.; Gacser, Attila; Goldman, David L.
In: Mycopathologia, Vol. 172, No. 3, 09.2011, p. 169-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Rat Model of Neonatal Candidiasis Demonstrates the Importance of Lipases as Virulence Factors for Candida albicans and Candida parapsilosis
AU - Trofa, David
AU - Soghier, Lamia
AU - Long, Christina
AU - Nosanchuk, Joshua D.
AU - Gacser, Attila
AU - Goldman, David L.
PY - 2011/9
Y1 - 2011/9
N2 - The host factors that contribute to the increased susceptibility of preterm neonates to invasive candidiasis have not been fully identified. In addition, there has been a lack of suitable models to study this problem. We show that rat pups, similar to premature neonates, display increased susceptibility to experimental Candida albicans infection. Further, we find that both C. albicans and Candida parapsilosis lipase disruptant mutants exhibit decreased virulence in rat pups, demonstrating the utility of the model to evaluate the impact of specific genes in disease pathogenesis. Our findings highlight the contribution of lipases to the virulence of C. albicans and C. parapsilosis and provide a new system to study the increased susceptibility of neonates to Candida infections.
AB - The host factors that contribute to the increased susceptibility of preterm neonates to invasive candidiasis have not been fully identified. In addition, there has been a lack of suitable models to study this problem. We show that rat pups, similar to premature neonates, display increased susceptibility to experimental Candida albicans infection. Further, we find that both C. albicans and Candida parapsilosis lipase disruptant mutants exhibit decreased virulence in rat pups, demonstrating the utility of the model to evaluate the impact of specific genes in disease pathogenesis. Our findings highlight the contribution of lipases to the virulence of C. albicans and C. parapsilosis and provide a new system to study the increased susceptibility of neonates to Candida infections.
KW - Candida
KW - Infection model
KW - Lipases
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=79960574755&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960574755&partnerID=8YFLogxK
U2 - 10.1007/s11046-011-9429-3
DO - 10.1007/s11046-011-9429-3
M3 - Article
C2 - 21667319
AN - SCOPUS:79960574755
VL - 172
SP - 169
EP - 178
JO - Mycopathologia
JF - Mycopathologia
SN - 0301-486X
IS - 3
ER -