A Rat Model of Neonatal Candidiasis Demonstrates the Importance of Lipases as Virulence Factors for Candida albicans and Candida parapsilosis

David Trofa, Lamia Soghier, Christina Long, Joshua D. Nosanchuk, Attila Gacser, David L. Goldman

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The host factors that contribute to the increased susceptibility of preterm neonates to invasive candidiasis have not been fully identified. In addition, there has been a lack of suitable models to study this problem. We show that rat pups, similar to premature neonates, display increased susceptibility to experimental Candida albicans infection. Further, we find that both C. albicans and Candida parapsilosis lipase disruptant mutants exhibit decreased virulence in rat pups, demonstrating the utility of the model to evaluate the impact of specific genes in disease pathogenesis. Our findings highlight the contribution of lipases to the virulence of C. albicans and C. parapsilosis and provide a new system to study the increased susceptibility of neonates to Candida infections.

Original languageEnglish (US)
Pages (from-to)169-178
Number of pages10
JournalMycopathologia
Volume172
Issue number3
DOIs
StatePublished - Sep 1 2011

Keywords

  • Candida
  • Infection model
  • Lipases
  • Rat

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology
  • Agronomy and Crop Science
  • veterinary (miscalleneous)

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