A rapid, novel method of volumetric assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis

C. Ratzlaff, A. Guermazi, J. Collins, J. N. Katz, E. Losina, C. Vanwyngaarden, R. Russell, Tannaz Iranpour Boroujeni, J. Duryea

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To assess reliability and validity of a semi-automated quantitative method for osteoarthritis (OA)-related bone marrow lesion (BML) assessment in the femur and tibia. Methods: In a cross-sectional study of subjects with knee OA, we examined concurrent criterion and clinical validation of a novel method of semi-automated quantitative BML measurement. The primary outcome was total segmented BML volume in femoral and tibial medial and lateral knee compartments. Criterion validation was examined through comparison of BML volumes with Whole-Organ Magnetic Resonance Imaging Score (WORMS) scoring. Clinical validation was examined via associations of tibial and femoral BML volume with the Western Ontario and McMaster University OA Index weight-bearing pain questions. Results: Among the 115 subjects, mean age was 62 years, mean BMI 30.4 (kg/m2), 84% were white and 52% male. The intra-class correlation coefficients (ICC) for intra-reader reliability was 0.96 and 0.97 for inter-reader reliability. Significant Spearman's correlations were found between segmented BML volume and WORMS BML scoring for tibial medial (0.75) and lateral (0.73) compartments, and for femoral medial (0.72) and lateral (0.88) compartments. Significant positive associations were found between weight-bearing pain and total femoral BML volume (P<0.003), but not total tibial BML (P<0.101). Conclusion: We have documented a moderately strong correlation between a novel measurement method of femoral and tibial BML volume and semi-quantitative WORMS scores, providing evidence of criterion validity. The hypothesis that weight-bearing pain was associated with BML volume was confirmed for total femoral BML volume but not total tibial BML volume. The lack of association between tibial BML volume and pain requires further investigation.

Original languageEnglish (US)
Pages (from-to)806-814
Number of pages9
JournalOsteoarthritis and Cartilage
Volume21
Issue number6
DOIs
StatePublished - Jun 2013
Externally publishedYes

Fingerprint

Knee Osteoarthritis
Magnetic resonance imaging
Bone
Bone Marrow
Thigh
Bearings (structural)
Weight-Bearing
Pain
Magnetic Resonance Imaging
Osteoarthritis
Organ Size
Ontario
Tibia
Reproducibility of Results
Femur
Knee

Keywords

  • Bone marrow lesions
  • Knee
  • Magnetic resonance imaging
  • Osteoarthritis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Ratzlaff, C., Guermazi, A., Collins, J., Katz, J. N., Losina, E., Vanwyngaarden, C., ... Duryea, J. (2013). A rapid, novel method of volumetric assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis. Osteoarthritis and Cartilage, 21(6), 806-814. https://doi.org/10.1016/j.joca.2013.03.007

A rapid, novel method of volumetric assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis. / Ratzlaff, C.; Guermazi, A.; Collins, J.; Katz, J. N.; Losina, E.; Vanwyngaarden, C.; Russell, R.; Iranpour Boroujeni, Tannaz; Duryea, J.

In: Osteoarthritis and Cartilage, Vol. 21, No. 6, 06.2013, p. 806-814.

Research output: Contribution to journalArticle

Ratzlaff, C, Guermazi, A, Collins, J, Katz, JN, Losina, E, Vanwyngaarden, C, Russell, R, Iranpour Boroujeni, T & Duryea, J 2013, 'A rapid, novel method of volumetric assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis', Osteoarthritis and Cartilage, vol. 21, no. 6, pp. 806-814. https://doi.org/10.1016/j.joca.2013.03.007
Ratzlaff, C. ; Guermazi, A. ; Collins, J. ; Katz, J. N. ; Losina, E. ; Vanwyngaarden, C. ; Russell, R. ; Iranpour Boroujeni, Tannaz ; Duryea, J. / A rapid, novel method of volumetric assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis. In: Osteoarthritis and Cartilage. 2013 ; Vol. 21, No. 6. pp. 806-814.
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abstract = "To assess reliability and validity of a semi-automated quantitative method for osteoarthritis (OA)-related bone marrow lesion (BML) assessment in the femur and tibia. Methods: In a cross-sectional study of subjects with knee OA, we examined concurrent criterion and clinical validation of a novel method of semi-automated quantitative BML measurement. The primary outcome was total segmented BML volume in femoral and tibial medial and lateral knee compartments. Criterion validation was examined through comparison of BML volumes with Whole-Organ Magnetic Resonance Imaging Score (WORMS) scoring. Clinical validation was examined via associations of tibial and femoral BML volume with the Western Ontario and McMaster University OA Index weight-bearing pain questions. Results: Among the 115 subjects, mean age was 62 years, mean BMI 30.4 (kg/m2), 84{\%} were white and 52{\%} male. The intra-class correlation coefficients (ICC) for intra-reader reliability was 0.96 and 0.97 for inter-reader reliability. Significant Spearman's correlations were found between segmented BML volume and WORMS BML scoring for tibial medial (0.75) and lateral (0.73) compartments, and for femoral medial (0.72) and lateral (0.88) compartments. Significant positive associations were found between weight-bearing pain and total femoral BML volume (P<0.003), but not total tibial BML (P<0.101). Conclusion: We have documented a moderately strong correlation between a novel measurement method of femoral and tibial BML volume and semi-quantitative WORMS scores, providing evidence of criterion validity. The hypothesis that weight-bearing pain was associated with BML volume was confirmed for total femoral BML volume but not total tibial BML volume. The lack of association between tibial BML volume and pain requires further investigation.",
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AU - Collins, J.

AU - Katz, J. N.

AU - Losina, E.

AU - Vanwyngaarden, C.

AU - Russell, R.

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N2 - To assess reliability and validity of a semi-automated quantitative method for osteoarthritis (OA)-related bone marrow lesion (BML) assessment in the femur and tibia. Methods: In a cross-sectional study of subjects with knee OA, we examined concurrent criterion and clinical validation of a novel method of semi-automated quantitative BML measurement. The primary outcome was total segmented BML volume in femoral and tibial medial and lateral knee compartments. Criterion validation was examined through comparison of BML volumes with Whole-Organ Magnetic Resonance Imaging Score (WORMS) scoring. Clinical validation was examined via associations of tibial and femoral BML volume with the Western Ontario and McMaster University OA Index weight-bearing pain questions. Results: Among the 115 subjects, mean age was 62 years, mean BMI 30.4 (kg/m2), 84% were white and 52% male. The intra-class correlation coefficients (ICC) for intra-reader reliability was 0.96 and 0.97 for inter-reader reliability. Significant Spearman's correlations were found between segmented BML volume and WORMS BML scoring for tibial medial (0.75) and lateral (0.73) compartments, and for femoral medial (0.72) and lateral (0.88) compartments. Significant positive associations were found between weight-bearing pain and total femoral BML volume (P<0.003), but not total tibial BML (P<0.101). Conclusion: We have documented a moderately strong correlation between a novel measurement method of femoral and tibial BML volume and semi-quantitative WORMS scores, providing evidence of criterion validity. The hypothesis that weight-bearing pain was associated with BML volume was confirmed for total femoral BML volume but not total tibial BML volume. The lack of association between tibial BML volume and pain requires further investigation.

AB - To assess reliability and validity of a semi-automated quantitative method for osteoarthritis (OA)-related bone marrow lesion (BML) assessment in the femur and tibia. Methods: In a cross-sectional study of subjects with knee OA, we examined concurrent criterion and clinical validation of a novel method of semi-automated quantitative BML measurement. The primary outcome was total segmented BML volume in femoral and tibial medial and lateral knee compartments. Criterion validation was examined through comparison of BML volumes with Whole-Organ Magnetic Resonance Imaging Score (WORMS) scoring. Clinical validation was examined via associations of tibial and femoral BML volume with the Western Ontario and McMaster University OA Index weight-bearing pain questions. Results: Among the 115 subjects, mean age was 62 years, mean BMI 30.4 (kg/m2), 84% were white and 52% male. The intra-class correlation coefficients (ICC) for intra-reader reliability was 0.96 and 0.97 for inter-reader reliability. Significant Spearman's correlations were found between segmented BML volume and WORMS BML scoring for tibial medial (0.75) and lateral (0.73) compartments, and for femoral medial (0.72) and lateral (0.88) compartments. Significant positive associations were found between weight-bearing pain and total femoral BML volume (P<0.003), but not total tibial BML (P<0.101). Conclusion: We have documented a moderately strong correlation between a novel measurement method of femoral and tibial BML volume and semi-quantitative WORMS scores, providing evidence of criterion validity. The hypothesis that weight-bearing pain was associated with BML volume was confirmed for total femoral BML volume but not total tibial BML volume. The lack of association between tibial BML volume and pain requires further investigation.

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