A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury

Mark K. Lyons, Michael D. Partington, Fredric B. Meyer, Gary M. Yarkony, Elliot J. Roth, Moris Senegor, Henry G. Stifel, Margaret Brown, Michael B. Bracken, Mary jo Shepard, William F. Collins, Theodore R. Holford, Wise Young, Joseph Piepmeier, Linda Leo-Summers, David S. Baskin, Howard M. Eisenberg, Eugene S. Flamm, Lawrence F. Marshall, Joseph MaroonJack Wilberger, Phanor L. Perot, Volker K.h. Sonntag, Franklin C. Wagner, H. Richard Winn

Research output: Contribution to journalLetter

5 Citations (Scopus)

Abstract

To the Editor: After reading the recent article by Bracken et al. (May 17 issue),1 we have several questions regarding data not discussed that would facilitate our analysis of this very important work. First, we understand from the description of the neurologic examination that proprioceptive function was not recorded and that in patients with a “complete” injury, proprioception may have been intact. A recent study suggests that the presence or absence of proprioception is strongly predictive of neurologic outcome in patients with acute spinal-cord injury.2 Bracken et al.3 reported previously that a complete sensory examination (including tests of proprioception) was.

Original languageEnglish (US)
Pages (from-to)1207-1209
Number of pages3
JournalNew England Journal of Medicine
Volume323
Issue number17
DOIs
StatePublished - Oct 25 1990
Externally publishedYes

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Proprioception
Methylprednisolone
Naloxone
Spinal Cord Injuries
Randomized Controlled Trials
Neurologic Examination
Nervous System
Reading
Spinal Cord
Therapeutics
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lyons, M. K., Partington, M. D., Meyer, F. B., Yarkony, G. M., Roth, E. J., Senegor, M., ... Winn, H. R. (1990). A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. New England Journal of Medicine, 323(17), 1207-1209. https://doi.org/10.1056/NEJM199010253231712

A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. / Lyons, Mark K.; Partington, Michael D.; Meyer, Fredric B.; Yarkony, Gary M.; Roth, Elliot J.; Senegor, Moris; Stifel, Henry G.; Brown, Margaret; Bracken, Michael B.; Shepard, Mary jo; Collins, William F.; Holford, Theodore R.; Young, Wise; Piepmeier, Joseph; Leo-Summers, Linda; Baskin, David S.; Eisenberg, Howard M.; Flamm, Eugene S.; Marshall, Lawrence F.; Maroon, Joseph; Wilberger, Jack; Perot, Phanor L.; Sonntag, Volker K.h.; Wagner, Franklin C.; Winn, H. Richard.

In: New England Journal of Medicine, Vol. 323, No. 17, 25.10.1990, p. 1207-1209.

Research output: Contribution to journalLetter

Lyons, MK, Partington, MD, Meyer, FB, Yarkony, GM, Roth, EJ, Senegor, M, Stifel, HG, Brown, M, Bracken, MB, Shepard, MJ, Collins, WF, Holford, TR, Young, W, Piepmeier, J, Leo-Summers, L, Baskin, DS, Eisenberg, HM, Flamm, ES, Marshall, LF, Maroon, J, Wilberger, J, Perot, PL, Sonntag, VKH, Wagner, FC & Winn, HR 1990, 'A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury', New England Journal of Medicine, vol. 323, no. 17, pp. 1207-1209. https://doi.org/10.1056/NEJM199010253231712
Lyons, Mark K. ; Partington, Michael D. ; Meyer, Fredric B. ; Yarkony, Gary M. ; Roth, Elliot J. ; Senegor, Moris ; Stifel, Henry G. ; Brown, Margaret ; Bracken, Michael B. ; Shepard, Mary jo ; Collins, William F. ; Holford, Theodore R. ; Young, Wise ; Piepmeier, Joseph ; Leo-Summers, Linda ; Baskin, David S. ; Eisenberg, Howard M. ; Flamm, Eugene S. ; Marshall, Lawrence F. ; Maroon, Joseph ; Wilberger, Jack ; Perot, Phanor L. ; Sonntag, Volker K.h. ; Wagner, Franklin C. ; Winn, H. Richard. / A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. In: New England Journal of Medicine. 1990 ; Vol. 323, No. 17. pp. 1207-1209.
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AU - Yarkony, Gary M.

AU - Roth, Elliot J.

AU - Senegor, Moris

AU - Stifel, Henry G.

AU - Brown, Margaret

AU - Bracken, Michael B.

AU - Shepard, Mary jo

AU - Collins, William F.

AU - Holford, Theodore R.

AU - Young, Wise

AU - Piepmeier, Joseph

AU - Leo-Summers, Linda

AU - Baskin, David S.

AU - Eisenberg, Howard M.

AU - Flamm, Eugene S.

AU - Marshall, Lawrence F.

AU - Maroon, Joseph

AU - Wilberger, Jack

AU - Perot, Phanor L.

AU - Sonntag, Volker K.h.

AU - Wagner, Franklin C.

AU - Winn, H. Richard

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N2 - To the Editor: After reading the recent article by Bracken et al. (May 17 issue),1 we have several questions regarding data not discussed that would facilitate our analysis of this very important work. First, we understand from the description of the neurologic examination that proprioceptive function was not recorded and that in patients with a “complete” injury, proprioception may have been intact. A recent study suggests that the presence or absence of proprioception is strongly predictive of neurologic outcome in patients with acute spinal-cord injury.2 Bracken et al.3 reported previously that a complete sensory examination (including tests of proprioception) was.

AB - To the Editor: After reading the recent article by Bracken et al. (May 17 issue),1 we have several questions regarding data not discussed that would facilitate our analysis of this very important work. First, we understand from the description of the neurologic examination that proprioceptive function was not recorded and that in patients with a “complete” injury, proprioception may have been intact. A recent study suggests that the presence or absence of proprioception is strongly predictive of neurologic outcome in patients with acute spinal-cord injury.2 Bracken et al.3 reported previously that a complete sensory examination (including tests of proprioception) was.

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