A prospective controlled study of magnetic resonance imaging of the brain in gay men and parenteral drug users with human immunodeficiency virus infection

G. Dooneief, Jacqueline A. Bello, G. Todak, I. K. Mun, K. Marder, R. Malouf, J. Gorman, S. Hilal, Y. Stern, R. Mayeux

Research output: Contribution to journalArticle

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Abstract

To detect the earliest structural changes in the brain in human immunodeficiency virus (HIV) infection, 118 gay men and 115 parenteral drug users enrolled in a study of the natural history of HIV infection underwent magnetic resonance imaging evaluations. Routine T2-weighted and heavily T2-weighted scans for quantification of brain water were obtained, blinded to HIV serostatus. Atrophy and foci of increased signal did not correlate with any medical, immunologic, neurologic, or neuropsychologic parameters in the group as a whole, or in the gay men or parenteral drug user subgroups. Three subjects had progressive multifocal leukoencephalopathy and one had central nervous system lymphoma. In a subgroup in whom intracranial water percent was calculated, correlations were found with CD4 counts and CD4/CD8 ratios. We conclude that standard magnetic resonance imaging of the brain does not differentiate asymptomatic and mildly symptomatic HIV-positive individuals from HIV-negative individuals, regardless of risk group. However, intracranial water percent may distinguish HIV-positive from HIV-negative individuals because it correlates with raw CD4 counts and CD4/CD8 ratios.

Original languageEnglish (US)
Pages (from-to)38-43
Number of pages6
JournalArchives of Neurology
Volume49
Issue number1
StatePublished - 1992
Externally publishedYes

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Virus Diseases
Drug Users
Magnetic Resonance Imaging
HIV
Prospective Studies
Brain
CD4-CD8 Ratio
CD4 Lymphocyte Count
Water
Progressive Multifocal Leukoencephalopathy
Sexual Minorities
Gay Men
AIDS/HIV
Drugs
Controlled
Natural History
Nervous System
Atrophy
Lymphoma
Central Nervous System

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A prospective controlled study of magnetic resonance imaging of the brain in gay men and parenteral drug users with human immunodeficiency virus infection. / Dooneief, G.; Bello, Jacqueline A.; Todak, G.; Mun, I. K.; Marder, K.; Malouf, R.; Gorman, J.; Hilal, S.; Stern, Y.; Mayeux, R.

In: Archives of Neurology, Vol. 49, No. 1, 1992, p. 38-43.

Research output: Contribution to journalArticle

Dooneief, G, Bello, JA, Todak, G, Mun, IK, Marder, K, Malouf, R, Gorman, J, Hilal, S, Stern, Y & Mayeux, R 1992, 'A prospective controlled study of magnetic resonance imaging of the brain in gay men and parenteral drug users with human immunodeficiency virus infection', Archives of Neurology, vol. 49, no. 1, pp. 38-43.
Dooneief, G. ; Bello, Jacqueline A. ; Todak, G. ; Mun, I. K. ; Marder, K. ; Malouf, R. ; Gorman, J. ; Hilal, S. ; Stern, Y. ; Mayeux, R. / A prospective controlled study of magnetic resonance imaging of the brain in gay men and parenteral drug users with human immunodeficiency virus infection. In: Archives of Neurology. 1992 ; Vol. 49, No. 1. pp. 38-43.
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