A prospective comparison of neuropsychologic function in HIV-seropositive and seronegative methadone-maintained patients

F. Patrick McKegney, Mary A. O'Dowd, Cheryl Feiner, Peter A. Selwyn, Ernest Drucker, Gerald H. Friedland

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

A prospective longitudinal study of neuropsychological and psychosocial functioning in a methadone-maintained population was initiated to test the hypothesis that cognitive impairments may be present early in the course of HIV infection, before the onset of other physical symptoms. A total of 220 methadone-clinic patients without evidence of HIV-related illnesses were given baseline psychological screening tests, as well as serological testing for HIV antibodies. At baseline, 83 (38%) had antibodies to HIV and 137 (62%) did not. On initial testing, controlling for race/ethnicity, age, sex and drug use, the seropositives were more cognitively impaired than the seronegatives. The differences were statistically significant for three subtests on univariate analysis: finger tapping (dominant), digit span (forward) and similarities. Ninety-one patients whose current serological status was known were given follow-up neuropsychological and psychosocial assessments after a mean interval of 7.4 months from baseline testing. At follow-up, seropositives continued to be more cognitively impaired than seronegatives, but there was no deterioration in the performance of the initial seropositives over the time interval.

Original languageEnglish (US)
Pages (from-to)565-569
Number of pages5
JournalAIDS
Volume4
Issue number6
StatePublished - Jun 1990

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HIV Antibodies
Methadone
HIV
Psychological Tests
Fingers
HIV Infections
Longitudinal Studies
Prospective Studies
Pharmaceutical Preparations
Population
Cognitive Dysfunction

Keywords

  • Neuropsychologic function in HIV positives
  • Neuropsychologic function in intravenous drug users
  • Psychosocial distress in HIV positives

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

A prospective comparison of neuropsychologic function in HIV-seropositive and seronegative methadone-maintained patients. / McKegney, F. Patrick; O'Dowd, Mary A.; Feiner, Cheryl; Selwyn, Peter A.; Drucker, Ernest; Friedland, Gerald H.

In: AIDS, Vol. 4, No. 6, 06.1990, p. 565-569.

Research output: Contribution to journalArticle

McKegney, F. Patrick ; O'Dowd, Mary A. ; Feiner, Cheryl ; Selwyn, Peter A. ; Drucker, Ernest ; Friedland, Gerald H. / A prospective comparison of neuropsychologic function in HIV-seropositive and seronegative methadone-maintained patients. In: AIDS. 1990 ; Vol. 4, No. 6. pp. 565-569.
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