A practical ECG criterion to unmask left accessory av connections in patients with subtle preexcitation

J. Jenkins Thompson, Jignesh Shah, Richard Charnigo, Andrea Tackett, Yousef H. Darrat, Alison Bailey, Brian Delisle, Bahram Kakavand, Luigi Di Biase, Andrea Natale, Gustavo Morales, Claude S. Elayi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

New ECG Criteria for Left-Sided AV Connections Background Accessory AV-connections capable of antegrade conduction need to be recognized because of the potential for life-threatening arrhythmias. However, the preexcited ECG pattern may be subtle, especially among left-sided AV-connections. We explored whether additional ECG criteria might help identify left-sided AV-connections. Methods We analyzed 156 patients who underwent an electrophysiology study (EPS) and ablation for paroxysmal supraventricular tachycardias (PSVT). Patients were divided into 2 groups: those with left-sided AV-connections (Group 1) and all other PSVT (Group 2). Various ECG parameters were compared before and after ablation in both groups. Results The EPS identified left-sided AV-connections among 43 patients (Group 1) and excluded it among 113 (Group 2). Baseline ECG in Group 1 demonstrated obvious preexcitation among 24/43 patients (55.8%), the remaining 19/43 missing obvious preexcitation. R/S ratio > 0.5 in V1 was noted in 38/43 (88.4%) patients in Group 1 before ablation (median 1.00; IQR 0.58-2.20), including 16/19 (84.2%) patients lacking obvious left-sided AVconnections. Conversely, only 10/113 (8.8%) patients in Group 2 had R/S ratios in V1 ≥ 0.5 (0.20; 0.10-0.31), P < 0.0001. After ablation, the R/S ratio decreased significantly in Group 1 (0.29; 0.17-0.45), P < 0.0001. Thus, a combined criterion of classic preexcitation or R/S ratio ≥ 0.5 on ECG identified 40/43 left-sided AV-connections (sensitivity 93.0%). The negative predictive value of this combined criterion was 103/106 (97.2%). Conclusions In symptomatic patients, combining the R/S ratio (≥ 0.5) in lead V1 with the classic preexcitation pattern on ECG markedly improved the sensitivity to diagnose left-sided AV-connections. This ratio may be particularly useful among patients lacking obvious preexcitation.

Original languageEnglish (US)
Pages (from-to)978-984
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Fingerprint

Electrocardiography
Paroxysmal Tachycardia
Supraventricular Tachycardia
Electrophysiology
Cardiac Arrhythmias

Keywords

  • ablation
  • accessory AV connections
  • accessory pathway
  • left accessory pathways
  • preexcitation
  • supraventricular tachycardia
  • Wolff-Parkinson-White syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Thompson, J. J., Shah, J., Charnigo, R., Tackett, A., Darrat, Y. H., Bailey, A., ... Elayi, C. S. (2015). A practical ECG criterion to unmask left accessory av connections in patients with subtle preexcitation. Journal of Cardiovascular Electrophysiology, 26(9), 978-984. https://doi.org/10.1111/jce.12711

A practical ECG criterion to unmask left accessory av connections in patients with subtle preexcitation. / Thompson, J. Jenkins; Shah, Jignesh; Charnigo, Richard; Tackett, Andrea; Darrat, Yousef H.; Bailey, Alison; Delisle, Brian; Kakavand, Bahram; Di Biase, Luigi; Natale, Andrea; Morales, Gustavo; Elayi, Claude S.

In: Journal of Cardiovascular Electrophysiology, Vol. 26, No. 9, 01.09.2015, p. 978-984.

Research output: Contribution to journalArticle

Thompson, JJ, Shah, J, Charnigo, R, Tackett, A, Darrat, YH, Bailey, A, Delisle, B, Kakavand, B, Di Biase, L, Natale, A, Morales, G & Elayi, CS 2015, 'A practical ECG criterion to unmask left accessory av connections in patients with subtle preexcitation', Journal of Cardiovascular Electrophysiology, vol. 26, no. 9, pp. 978-984. https://doi.org/10.1111/jce.12711
Thompson, J. Jenkins ; Shah, Jignesh ; Charnigo, Richard ; Tackett, Andrea ; Darrat, Yousef H. ; Bailey, Alison ; Delisle, Brian ; Kakavand, Bahram ; Di Biase, Luigi ; Natale, Andrea ; Morales, Gustavo ; Elayi, Claude S. / A practical ECG criterion to unmask left accessory av connections in patients with subtle preexcitation. In: Journal of Cardiovascular Electrophysiology. 2015 ; Vol. 26, No. 9. pp. 978-984.
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abstract = "New ECG Criteria for Left-Sided AV Connections Background Accessory AV-connections capable of antegrade conduction need to be recognized because of the potential for life-threatening arrhythmias. However, the preexcited ECG pattern may be subtle, especially among left-sided AV-connections. We explored whether additional ECG criteria might help identify left-sided AV-connections. Methods We analyzed 156 patients who underwent an electrophysiology study (EPS) and ablation for paroxysmal supraventricular tachycardias (PSVT). Patients were divided into 2 groups: those with left-sided AV-connections (Group 1) and all other PSVT (Group 2). Various ECG parameters were compared before and after ablation in both groups. Results The EPS identified left-sided AV-connections among 43 patients (Group 1) and excluded it among 113 (Group 2). Baseline ECG in Group 1 demonstrated obvious preexcitation among 24/43 patients (55.8{\%}), the remaining 19/43 missing obvious preexcitation. R/S ratio > 0.5 in V1 was noted in 38/43 (88.4{\%}) patients in Group 1 before ablation (median 1.00; IQR 0.58-2.20), including 16/19 (84.2{\%}) patients lacking obvious left-sided AVconnections. Conversely, only 10/113 (8.8{\%}) patients in Group 2 had R/S ratios in V1 ≥ 0.5 (0.20; 0.10-0.31), P < 0.0001. After ablation, the R/S ratio decreased significantly in Group 1 (0.29; 0.17-0.45), P < 0.0001. Thus, a combined criterion of classic preexcitation or R/S ratio ≥ 0.5 on ECG identified 40/43 left-sided AV-connections (sensitivity 93.0{\%}). The negative predictive value of this combined criterion was 103/106 (97.2{\%}). Conclusions In symptomatic patients, combining the R/S ratio (≥ 0.5) in lead V1 with the classic preexcitation pattern on ECG markedly improved the sensitivity to diagnose left-sided AV-connections. This ratio may be particularly useful among patients lacking obvious preexcitation.",
keywords = "ablation, accessory AV connections, accessory pathway, left accessory pathways, preexcitation, supraventricular tachycardia, Wolff-Parkinson-White syndrome",
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AU - Darrat, Yousef H.

AU - Bailey, Alison

AU - Delisle, Brian

AU - Kakavand, Bahram

AU - Di Biase, Luigi

AU - Natale, Andrea

AU - Morales, Gustavo

AU - Elayi, Claude S.

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N2 - New ECG Criteria for Left-Sided AV Connections Background Accessory AV-connections capable of antegrade conduction need to be recognized because of the potential for life-threatening arrhythmias. However, the preexcited ECG pattern may be subtle, especially among left-sided AV-connections. We explored whether additional ECG criteria might help identify left-sided AV-connections. Methods We analyzed 156 patients who underwent an electrophysiology study (EPS) and ablation for paroxysmal supraventricular tachycardias (PSVT). Patients were divided into 2 groups: those with left-sided AV-connections (Group 1) and all other PSVT (Group 2). Various ECG parameters were compared before and after ablation in both groups. Results The EPS identified left-sided AV-connections among 43 patients (Group 1) and excluded it among 113 (Group 2). Baseline ECG in Group 1 demonstrated obvious preexcitation among 24/43 patients (55.8%), the remaining 19/43 missing obvious preexcitation. R/S ratio > 0.5 in V1 was noted in 38/43 (88.4%) patients in Group 1 before ablation (median 1.00; IQR 0.58-2.20), including 16/19 (84.2%) patients lacking obvious left-sided AVconnections. Conversely, only 10/113 (8.8%) patients in Group 2 had R/S ratios in V1 ≥ 0.5 (0.20; 0.10-0.31), P < 0.0001. After ablation, the R/S ratio decreased significantly in Group 1 (0.29; 0.17-0.45), P < 0.0001. Thus, a combined criterion of classic preexcitation or R/S ratio ≥ 0.5 on ECG identified 40/43 left-sided AV-connections (sensitivity 93.0%). The negative predictive value of this combined criterion was 103/106 (97.2%). Conclusions In symptomatic patients, combining the R/S ratio (≥ 0.5) in lead V1 with the classic preexcitation pattern on ECG markedly improved the sensitivity to diagnose left-sided AV-connections. This ratio may be particularly useful among patients lacking obvious preexcitation.

AB - New ECG Criteria for Left-Sided AV Connections Background Accessory AV-connections capable of antegrade conduction need to be recognized because of the potential for life-threatening arrhythmias. However, the preexcited ECG pattern may be subtle, especially among left-sided AV-connections. We explored whether additional ECG criteria might help identify left-sided AV-connections. Methods We analyzed 156 patients who underwent an electrophysiology study (EPS) and ablation for paroxysmal supraventricular tachycardias (PSVT). Patients were divided into 2 groups: those with left-sided AV-connections (Group 1) and all other PSVT (Group 2). Various ECG parameters were compared before and after ablation in both groups. Results The EPS identified left-sided AV-connections among 43 patients (Group 1) and excluded it among 113 (Group 2). Baseline ECG in Group 1 demonstrated obvious preexcitation among 24/43 patients (55.8%), the remaining 19/43 missing obvious preexcitation. R/S ratio > 0.5 in V1 was noted in 38/43 (88.4%) patients in Group 1 before ablation (median 1.00; IQR 0.58-2.20), including 16/19 (84.2%) patients lacking obvious left-sided AVconnections. Conversely, only 10/113 (8.8%) patients in Group 2 had R/S ratios in V1 ≥ 0.5 (0.20; 0.10-0.31), P < 0.0001. After ablation, the R/S ratio decreased significantly in Group 1 (0.29; 0.17-0.45), P < 0.0001. Thus, a combined criterion of classic preexcitation or R/S ratio ≥ 0.5 on ECG identified 40/43 left-sided AV-connections (sensitivity 93.0%). The negative predictive value of this combined criterion was 103/106 (97.2%). Conclusions In symptomatic patients, combining the R/S ratio (≥ 0.5) in lead V1 with the classic preexcitation pattern on ECG markedly improved the sensitivity to diagnose left-sided AV-connections. This ratio may be particularly useful among patients lacking obvious preexcitation.

KW - ablation

KW - accessory AV connections

KW - accessory pathway

KW - left accessory pathways

KW - preexcitation

KW - supraventricular tachycardia

KW - Wolff-Parkinson-White syndrome

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