A pilot study of oral sumatriptan as intermittent prophylaxis of menstruation-related migraine

Lawrence C. Newman, Richard B. Lipton, Christine L. Lay, Seymour Solomon

Research output: Contribution to journalArticle

109 Scopus citations


Headaches associated with menstruation are often resistant to abortive and preventative medications. We performed an open-label study in 20 female migraineurs, employing oral sumatriptan perimenstrually as short-term prophylaxis of menstrual migraine. In 126 sumatriptan-treated cycles, headache was absent in 52.4% and reduced in severity by 50% or greater in 42%. Breakthrough headaches were rare and significantly reduced in severity compared with baseline headaches.

Original languageEnglish (US)
Pages (from-to)307-309
Number of pages3
Issue number1
StatePublished - Jul 1998


ASJC Scopus subject areas

  • Clinical Neurology

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