A pilot study of oral sumatriptan as intermittent prophylaxis of menstruation-related migraine

Lawrence C. Newman; Richard B. Lipton; Christine L. Lay; Seymour Solomon

doi:10.1212/WNL.51.1.307

A pilot study of oral sumatriptan as intermittent prophylaxis of menstruation-related migraine

Lawrence C. Newman, Richard B. Lipton, Christine L. Lay, Seymour Solomon

Neurology

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

Headaches associated with menstruation are often resistant to abortive and preventative medications. We performed an open-label study in 20 female migraineurs, employing oral sumatriptan perimenstrually as short-term prophylaxis of menstrual migraine. In 126 sumatriptan-treated cycles, headache was absent in 52.4% and reduced in severity by 50% or greater in 42%. Breakthrough headaches were rare and significantly reduced in severity compared with baseline headaches.

Original language	English (US)
Pages (from-to)	307-309
Number of pages	3
Journal	Neurology
Volume	51
Issue number	1
DOIs	https://doi.org/10.1212/WNL.51.1.307
State	Published - Jul 1998

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Headaches associated with menstruation are often resistant to abortive and preventative medications. We performed an open-label study in 20 female migraineurs, employing oral sumatriptan perimenstrually as short-term prophylaxis of menstrual migraine. In 126 sumatriptan-treated cycles, headache was absent in 52.4% and reduced in severity by 50% or greater in 42%. Breakthrough headaches were rare and significantly reduced in severity compared with baseline headaches.",

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AB - Headaches associated with menstruation are often resistant to abortive and preventative medications. We performed an open-label study in 20 female migraineurs, employing oral sumatriptan perimenstrually as short-term prophylaxis of menstrual migraine. In 126 sumatriptan-treated cycles, headache was absent in 52.4% and reduced in severity by 50% or greater in 42%. Breakthrough headaches were rare and significantly reduced in severity compared with baseline headaches.

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A pilot study of oral sumatriptan as intermittent prophylaxis of menstruation-related migraine

Abstract

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