A novel serum chitinase that is expressed in bovine liver

Masako Suzuki; Masami Morimatsu; Tetsuro Yamashita; Toshihiko Iwanaga; Bunei Syuto

doi:10.1016/S0014-5793(01)02893-9

A novel serum chitinase that is expressed in bovine liver

Masako Suzuki, Masami Morimatsu, Tetsuro Yamashita, Toshihiko Iwanaga, Bunei Syuto

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Chitinases are ubiquitous chitin-fragmenting hydrolases. They are synthesized by a vast array of organisms, including those not composed of chitin. Here, we describe a novel serum chitinase (chitin-binding protein b04, CBPb04), which is expressed in bovine liver. Although CBPb04 is secreted as an endocrine chitinase, it shows higher homology with human gastrointestinal tract exocrine chitinase (AMCase) than with macrophage endocrine chitinase (human chitotriosidase). This suggests that cows have a specific defense against chitin-containing microorganisms. CBPb04 mRNA is expressed in hepatocytes. This is the first report of a hepatogenic mammalian chitinase.

Original language	English (US)
Pages (from-to)	127-130
Number of pages	4
Journal	FEBS Letters
Volume	506
Issue number	2
DOIs	https://doi.org/10.1016/S0014-5793(01)02893-9
State	Published - Oct 5 2001
Externally published	Yes

Keywords

Bovine serum
Chitin
Innate immunity
Liver
Mammalian chitinase

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/S0014-5793(01)02893-9

Cite this

@article{ff9d9a1ec0eb4e29997c4cb0b4fa33a4,

title = "A novel serum chitinase that is expressed in bovine liver",

abstract = "Chitinases are ubiquitous chitin-fragmenting hydrolases. They are synthesized by a vast array of organisms, including those not composed of chitin. Here, we describe a novel serum chitinase (chitin-binding protein b04, CBPb04), which is expressed in bovine liver. Although CBPb04 is secreted as an endocrine chitinase, it shows higher homology with human gastrointestinal tract exocrine chitinase (AMCase) than with macrophage endocrine chitinase (human chitotriosidase). This suggests that cows have a specific defense against chitin-containing microorganisms. CBPb04 mRNA is expressed in hepatocytes. This is the first report of a hepatogenic mammalian chitinase.",

keywords = "Bovine serum, Chitin, Innate immunity, Liver, Mammalian chitinase",

author = "Masako Suzuki and Masami Morimatsu and Tetsuro Yamashita and Toshihiko Iwanaga and Bunei Syuto",

year = "2001",

month = oct,

day = "5",

doi = "10.1016/S0014-5793(01)02893-9",

language = "English (US)",

volume = "506",

pages = "127--130",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - A novel serum chitinase that is expressed in bovine liver

AU - Suzuki, Masako

AU - Morimatsu, Masami

AU - Yamashita, Tetsuro

AU - Iwanaga, Toshihiko

AU - Syuto, Bunei

PY - 2001/10/5

Y1 - 2001/10/5

N2 - Chitinases are ubiquitous chitin-fragmenting hydrolases. They are synthesized by a vast array of organisms, including those not composed of chitin. Here, we describe a novel serum chitinase (chitin-binding protein b04, CBPb04), which is expressed in bovine liver. Although CBPb04 is secreted as an endocrine chitinase, it shows higher homology with human gastrointestinal tract exocrine chitinase (AMCase) than with macrophage endocrine chitinase (human chitotriosidase). This suggests that cows have a specific defense against chitin-containing microorganisms. CBPb04 mRNA is expressed in hepatocytes. This is the first report of a hepatogenic mammalian chitinase.

AB - Chitinases are ubiquitous chitin-fragmenting hydrolases. They are synthesized by a vast array of organisms, including those not composed of chitin. Here, we describe a novel serum chitinase (chitin-binding protein b04, CBPb04), which is expressed in bovine liver. Although CBPb04 is secreted as an endocrine chitinase, it shows higher homology with human gastrointestinal tract exocrine chitinase (AMCase) than with macrophage endocrine chitinase (human chitotriosidase). This suggests that cows have a specific defense against chitin-containing microorganisms. CBPb04 mRNA is expressed in hepatocytes. This is the first report of a hepatogenic mammalian chitinase.

KW - Bovine serum

KW - Chitin

KW - Innate immunity

KW - Liver

KW - Mammalian chitinase

UR - http://www.scopus.com/inward/record.url?scp=0035812939&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035812939&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(01)02893-9

DO - 10.1016/S0014-5793(01)02893-9

M3 - Article

C2 - 11591385

AN - SCOPUS:0035812939

SN - 0014-5793

VL - 506

SP - 127

EP - 130

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

A novel serum chitinase that is expressed in bovine liver

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this