A novel serum chitinase that is expressed in bovine liver

Masako Suzuki, Masami Morimatsu, Tetsuro Yamashita, Toshihiko Iwanaga, Bunei Syuto

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Chitinases are ubiquitous chitin-fragmenting hydrolases. They are synthesized by a vast array of organisms, including those not composed of chitin. Here, we describe a novel serum chitinase (chitin-binding protein b04, CBPb04), which is expressed in bovine liver. Although CBPb04 is secreted as an endocrine chitinase, it shows higher homology with human gastrointestinal tract exocrine chitinase (AMCase) than with macrophage endocrine chitinase (human chitotriosidase). This suggests that cows have a specific defense against chitin-containing microorganisms. CBPb04 mRNA is expressed in hepatocytes. This is the first report of a hepatogenic mammalian chitinase.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalFEBS Letters
Issue number2
StatePublished - Oct 5 2001
Externally publishedYes


  • Bovine serum
  • Chitin
  • Innate immunity
  • Liver
  • Mammalian chitinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


Dive into the research topics of 'A novel serum chitinase that is expressed in bovine liver'. Together they form a unique fingerprint.

Cite this