A novel regulator of ER Ca2+ drives Hippo-mediated tumorigenesis

Xianjue Ma, Jin Yu Lu, Alexandra Moraru, Aurelio A. Teleman, Jinan Fang, Yue Qiu, Peng Liu, Tian Xu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Calcium ion (Ca2+) is a versatile second messenger that regulates various cellular and physiological functions. However, the in vivo molecular mechanisms by which Ca2+ alterations contribute to tumor growth remain poorly explored. Here we show that Emei is a novel ER Ca2+ regulator that synergizes with RasV12 to induce tumor growth via JNK-mediated Hippo signaling. Emei disruption reduces ER Ca2+ level and subsequently leads to JNK activation and Hippo inactivation. Importantly, genetically increasing cytosolic Ca2+ concentration cooperates with RasV12 to drive tumor growth via inactivating the Hippo pathway. Finally, we identify POSH as a crucial link that bridges cytosolic Ca2+ alteration with JNK activation and Hippo-mediated tumor growth. Together, our findings provide a novel mechanism of tumor growth that acts through intracellular Ca2+ levels to modulate JNK-mediated Hippo signaling.

Original languageEnglish (US)
Pages (from-to)1378-1387
Number of pages10
JournalOncogene
Volume39
Issue number6
DOIs
StatePublished - Feb 6 2020
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint

Dive into the research topics of 'A novel regulator of ER Ca2+ drives Hippo-mediated tumorigenesis'. Together they form a unique fingerprint.

Cite this