A novel pathway for secretory proteins?

Anne Muesch, Enno Hartmann, Klaus Rohde, Anna Rubartelli, Roberto Sitia, Tom A. Rapoport

Research output: Contribution to journalArticle

244 Citations (Scopus)

Abstract

In eukaryotes, most proteins which are transported to the extracellular space, into mitochondria or into chloroplasts are synthesized as precursor polypeptides containing cleavable N-terminal signal or targeting sequences. We have searched the literature for proteins that are exported from the cytosol without being proteolytically processed. Some of these proteins contain uncleaved signal or targeting sequences. However, among secretory proteins there is a class that does not possess hydrophobic signal sequences and appears to leave the cell by a secretory pathway clearly distinct from the classical route through the endoplasmic reticulum and Golgi apparatus.

Original languageEnglish (US)
Pages (from-to)86-88
Number of pages3
JournalTrends in Biochemical Sciences
Volume15
Issue number3
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Secretory Pathway
Proteins
Mitochondria
Extracellular Space
Golgi Apparatus
Chloroplasts
Protein Sorting Signals
Eukaryota
Endoplasmic Reticulum
Cytosol
Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Muesch, A., Hartmann, E., Rohde, K., Rubartelli, A., Sitia, R., & Rapoport, T. A. (1990). A novel pathway for secretory proteins? Trends in Biochemical Sciences, 15(3), 86-88. https://doi.org/10.1016/0968-0004(90)90186-F

A novel pathway for secretory proteins? / Muesch, Anne; Hartmann, Enno; Rohde, Klaus; Rubartelli, Anna; Sitia, Roberto; Rapoport, Tom A.

In: Trends in Biochemical Sciences, Vol. 15, No. 3, 01.01.1990, p. 86-88.

Research output: Contribution to journalArticle

Muesch, A, Hartmann, E, Rohde, K, Rubartelli, A, Sitia, R & Rapoport, TA 1990, 'A novel pathway for secretory proteins?', Trends in Biochemical Sciences, vol. 15, no. 3, pp. 86-88. https://doi.org/10.1016/0968-0004(90)90186-F
Muesch A, Hartmann E, Rohde K, Rubartelli A, Sitia R, Rapoport TA. A novel pathway for secretory proteins? Trends in Biochemical Sciences. 1990 Jan 1;15(3):86-88. https://doi.org/10.1016/0968-0004(90)90186-F
Muesch, Anne ; Hartmann, Enno ; Rohde, Klaus ; Rubartelli, Anna ; Sitia, Roberto ; Rapoport, Tom A. / A novel pathway for secretory proteins?. In: Trends in Biochemical Sciences. 1990 ; Vol. 15, No. 3. pp. 86-88.
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