A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin

Nir Barzilai, P. H. Groop, L. Groop, R. A. DeFronzo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To examine whether sulfonylureas inhibit the metabolic clearance rate (MCR) of insulin, 19 healthy young subjects participated in two experiments. In the first protocol (n=10), a 3-h oral glucose load was performed with and without 2 mg of glipizide given 30 min before glucose ingestion. The total insulin response was 60% greater with than without glipizide (5.9±0.6 vs 3.7±0.5 μU/ml;P<0.001). However, the total C-peptide responses were virtually identical (4.7±0.5 vs 4.8±0.4 nmol/l) in both studies. In the second protocol (n=9), the MCR of insulin was measured during 4-h euglycemic insulin clamps performed with and without glipizide. In the study with glipizide, the subjects ingested 5 mg of glipizide at 120 min. The steady-state plasma insulin concentration during the 4th h, i.e., 1-2 h after glipizide ingestion, was significantly higher than during the 2nd h, i.e., before glipizide ingestion (99±22 vs 78±17 μU/ml;P<0.01). In addition, glucose uptake during the 4th h was greater (8.0±1.6 vs 6.4±1.5 mg/kg·min) and the MCR of insulin was reduced (503±126 vs 621±176 ml/m2·min;P<0.01). We conclude that glipizide augments plasma insulin levels both by enhancing its secretion and by decreasing the MCR of insulin.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalActa Diabetologica
Volume32
Issue number4
DOIs
StatePublished - Dec 1995

Fingerprint

Glipizide
Metabolic Clearance Rate
Insulin
Eating
Glucose
Glucose Clamp Technique
C-Peptide
Healthy Volunteers

Keywords

  • C-peptide
  • Glipizide
  • Insulin
  • Insulin metabolic clearance rate (MCR)
  • Sulfonylurea

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

A novel mechanism of glipizide sulfonylurea action : decreased metabolic clearance rate of insulin. / Barzilai, Nir; Groop, P. H.; Groop, L.; DeFronzo, R. A.

In: Acta Diabetologica, Vol. 32, No. 4, 12.1995, p. 273-278.

Research output: Contribution to journalArticle

Barzilai, Nir ; Groop, P. H. ; Groop, L. ; DeFronzo, R. A. / A novel mechanism of glipizide sulfonylurea action : decreased metabolic clearance rate of insulin. In: Acta Diabetologica. 1995 ; Vol. 32, No. 4. pp. 273-278.
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