A mouse model of human familial adenomatous polyposis

Kan Yang, Winfried Edelmann, Kunhua Fan, Kirkland Lau, Venkateswara R. Kolli, Riccardo Fodde, P. Meera Khan, Raju Kucherlapati, Martin Lipkin

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps and tumors of the small intestine. Neoplasms were found in 96% of animals studied, and they included adenomas, adenocarcinomas, and polypoid hyperplasias. The mice developed an average of 3.3 tumors, with the highest number in duodenum, followed by jejunum, stomach, ileum, and colon. Focal areas of dysplasias were observed in the colonic mucosa in 50% of mice which were 10 months old or older. These results suggest that mice carrying the Apc1638 mutation can serve as a good model to study the initiation, progression, and inhibition of gastrointestinal tumors.

Original languageEnglish (US)
Pages (from-to)245-254
Number of pages10
JournalJournal of Experimental Zoology
Volume277
Issue number3
StatePublished - Feb 15 1997

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animal models
mice
mutation
neoplasms
adenoma
jejunum
adenocarcinoma
colorectal neoplasms
duodenum
hyperplasia
ileum
colon
mucosa
small intestine
stomach
animals
genes

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Yang, K., Edelmann, W., Fan, K., Lau, K., Kolli, V. R., Fodde, R., ... Lipkin, M. (1997). A mouse model of human familial adenomatous polyposis. Journal of Experimental Zoology, 277(3), 245-254.

A mouse model of human familial adenomatous polyposis. / Yang, Kan; Edelmann, Winfried; Fan, Kunhua; Lau, Kirkland; Kolli, Venkateswara R.; Fodde, Riccardo; Khan, P. Meera; Kucherlapati, Raju; Lipkin, Martin.

In: Journal of Experimental Zoology, Vol. 277, No. 3, 15.02.1997, p. 245-254.

Research output: Contribution to journalArticle

Yang, K, Edelmann, W, Fan, K, Lau, K, Kolli, VR, Fodde, R, Khan, PM, Kucherlapati, R & Lipkin, M 1997, 'A mouse model of human familial adenomatous polyposis', Journal of Experimental Zoology, vol. 277, no. 3, pp. 245-254.
Yang K, Edelmann W, Fan K, Lau K, Kolli VR, Fodde R et al. A mouse model of human familial adenomatous polyposis. Journal of Experimental Zoology. 1997 Feb 15;277(3):245-254.
Yang, Kan ; Edelmann, Winfried ; Fan, Kunhua ; Lau, Kirkland ; Kolli, Venkateswara R. ; Fodde, Riccardo ; Khan, P. Meera ; Kucherlapati, Raju ; Lipkin, Martin. / A mouse model of human familial adenomatous polyposis. In: Journal of Experimental Zoology. 1997 ; Vol. 277, No. 3. pp. 245-254.
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