A mouse model of human familial adenomatous polyposis

Kan Yang, Winfried Edelmann, Kunhua Fan, Kirkland Lau, Venkateswara R. Kolli, Riccardo Fodde, P. Meera Khan, Raju Kucherlapati, Martin Lipkin

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Abstract

In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps and tumors of the small intestine. Neoplasms were found in 96% of animals studied, and they included adenomas, adenocarcinomas, and polypoid hyperplasias. The mice developed an average of 3.3 tumors, with the highest number in duodenum, followed by jejunum, stomach, ileum, and colon. Focal areas of dysplasias were observed in the colonic mucosa in 50% of mice which were 10 months old or older. These results suggest that mice carrying the Apc1638 mutation can serve as a good model to study the initiation, progression, and inhibition of gastrointestinal tumors.

Original languageEnglish (US)
Pages (from-to)245-254
Number of pages10
JournalJournal of Experimental Zoology
Volume277
Issue number3
DOIs
Publication statusPublished - Feb 15 1997

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ASJC Scopus subject areas

  • Animal Science and Zoology

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