Abstract
Cell-surface glycoprotein receptors have varying numbers of N-glycan sites. In this issue of Cell, Lau et al. (2007) report that increasing intracellular UDP-GlcNAc leads to increased branching of N-glycans, increased receptor association with cell-surface galectin-3, and enhanced signaling. They also show that the kinetics of this response differ between growth-promoting receptors, which have 8-16 N-glycans, and those that induce growth arrest, which have very few N-glycans, suggesting that hexosamine flux may regulate the transition from growth to arrest.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-29 |
| Number of pages | 3 |
| Journal | Cell |
| Volume | 129 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 6 2007 |
Fingerprint
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
Cite this
A Method to the Madness of N-Glycan Complexity? / Stanley, Pamela.
In: Cell, Vol. 129, No. 1, 06.04.2007, p. 27-29.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Method to the Madness of N-Glycan Complexity?
AU - Stanley, Pamela
PY - 2007/4/6
Y1 - 2007/4/6
N2 - Cell-surface glycoprotein receptors have varying numbers of N-glycan sites. In this issue of Cell, Lau et al. (2007) report that increasing intracellular UDP-GlcNAc leads to increased branching of N-glycans, increased receptor association with cell-surface galectin-3, and enhanced signaling. They also show that the kinetics of this response differ between growth-promoting receptors, which have 8-16 N-glycans, and those that induce growth arrest, which have very few N-glycans, suggesting that hexosamine flux may regulate the transition from growth to arrest.
AB - Cell-surface glycoprotein receptors have varying numbers of N-glycan sites. In this issue of Cell, Lau et al. (2007) report that increasing intracellular UDP-GlcNAc leads to increased branching of N-glycans, increased receptor association with cell-surface galectin-3, and enhanced signaling. They also show that the kinetics of this response differ between growth-promoting receptors, which have 8-16 N-glycans, and those that induce growth arrest, which have very few N-glycans, suggesting that hexosamine flux may regulate the transition from growth to arrest.
UR - http://www.scopus.com/inward/record.url?scp=33947725535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947725535&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2007.03.022
DO - 10.1016/j.cell.2007.03.022
M3 - Article
C2 - 17418781
AN - SCOPUS:33947725535
VL - 129
SP - 27
EP - 29
JO - Cell
JF - Cell
SN - 0092-8674
IS - 1
ER -