Abstract
Cell-surface glycoprotein receptors have varying numbers of N-glycan sites. In this issue of Cell, Lau et al. (2007) report that increasing intracellular UDP-GlcNAc leads to increased branching of N-glycans, increased receptor association with cell-surface galectin-3, and enhanced signaling. They also show that the kinetics of this response differ between growth-promoting receptors, which have 8-16 N-glycans, and those that induce growth arrest, which have very few N-glycans, suggesting that hexosamine flux may regulate the transition from growth to arrest.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-29 |
| Number of pages | 3 |
| Journal | Cell |
| Volume | 129 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 6 2007 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Stanley, P. (2007). A Method to the Madness of N-Glycan Complexity? Cell, 129(1), 27-29. https://doi.org/10.1016/j.cell.2007.03.022