A Method to the Madness of N-Glycan Complexity?

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Cell-surface glycoprotein receptors have varying numbers of N-glycan sites. In this issue of Cell, Lau et al. (2007) report that increasing intracellular UDP-GlcNAc leads to increased branching of N-glycans, increased receptor association with cell-surface galectin-3, and enhanced signaling. They also show that the kinetics of this response differ between growth-promoting receptors, which have 8-16 N-glycans, and those that induce growth arrest, which have very few N-glycans, suggesting that hexosamine flux may regulate the transition from growth to arrest.

Original languageEnglish (US)
Pages (from-to)27-29
Number of pages3
JournalCell
Volume129
Issue number1
DOIs
StatePublished - Apr 6 2007

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Polysaccharides
Growth
Galectin 3
Hexosamines
Uridine Diphosphate
Membrane Glycoproteins
Cell Surface Receptors
Fluxes
Kinetics

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

A Method to the Madness of N-Glycan Complexity? / Stanley, Pamela.

In: Cell, Vol. 129, No. 1, 06.04.2007, p. 27-29.

Research output: Contribution to journalArticle

Stanley, Pamela. / A Method to the Madness of N-Glycan Complexity?. In: Cell. 2007 ; Vol. 129, No. 1. pp. 27-29.
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