TY - JOUR
T1 - A method for estimating and removing streaking artifacts in quantitative susceptibility mapping
AU - Li, Wei
AU - Wang, Nian
AU - Yu, Fang
AU - Han, Hui
AU - Cao, Wei
AU - Romero, Rebecca
AU - Tantiwongkosi, Bundhit
AU - Duong, Timothy Q.
AU - Liu, Chunlei
N1 - Funding Information:
This study was supported in part by the National Institutes of Health ( NIH ) through grants NIBIB P41 EB015897 , R21HL122759 and R01 MH096979 and by the National Multiple Sclerosis Society ( RG4723 ) to C.L. W.L. was also supported in part by UL1 TR001119 via the Clinical Translational Science Awards (CTSA) .
Publisher Copyright:
© 2014 .
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Quantitative susceptibility mapping (QSM) is a novel MRI method for quantifying tissue magnetic property. In the brain, it reflects the molecular composition and microstructure of the local tissue. However, susceptibility maps reconstructed from single-orientation data still suffer from streaking artifacts which obscure structural details and small lesions. We propose and have developed a general method for estimating streaking artifacts and subtracting them from susceptibility maps. Specifically, this method uses a sparse linear equation and least-squares (LSQR)-algorithm-based method to derive an initial estimation of magnetic susceptibility, a fast quantitative susceptibility mapping method to estimate the susceptibility boundaries, and an iterative approach to estimate the susceptibility artifact from ill-conditioned k-space regions only. With a fixed set of parameters for the initial susceptibility estimation and subsequent streaking artifact estimation and removal, the method provides an unbiased estimate of tissue susceptibility with negligible streaking artifacts, as compared to multi-orientation QSM reconstruction. This method allows for improved delineation of white matter lesions in patients with multiple sclerosis and small structures of the human brain with excellent anatomical details. The proposed methodology can be extended to other existing QSM algorithms.
AB - Quantitative susceptibility mapping (QSM) is a novel MRI method for quantifying tissue magnetic property. In the brain, it reflects the molecular composition and microstructure of the local tissue. However, susceptibility maps reconstructed from single-orientation data still suffer from streaking artifacts which obscure structural details and small lesions. We propose and have developed a general method for estimating streaking artifacts and subtracting them from susceptibility maps. Specifically, this method uses a sparse linear equation and least-squares (LSQR)-algorithm-based method to derive an initial estimation of magnetic susceptibility, a fast quantitative susceptibility mapping method to estimate the susceptibility boundaries, and an iterative approach to estimate the susceptibility artifact from ill-conditioned k-space regions only. With a fixed set of parameters for the initial susceptibility estimation and subsequent streaking artifact estimation and removal, the method provides an unbiased estimate of tissue susceptibility with negligible streaking artifacts, as compared to multi-orientation QSM reconstruction. This method allows for improved delineation of white matter lesions in patients with multiple sclerosis and small structures of the human brain with excellent anatomical details. The proposed methodology can be extended to other existing QSM algorithms.
KW - High resolution brain imaging
KW - Multiple sclerosis
KW - Quantitative susceptibility mapping
KW - Streaking artifact removal
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U2 - 10.1016/j.neuroimage.2014.12.043
DO - 10.1016/j.neuroimage.2014.12.043
M3 - Article
C2 - 25536496
AN - SCOPUS:84922601705
SN - 1053-8119
VL - 108
SP - 111
EP - 122
JO - NeuroImage
JF - NeuroImage
ER -