A kinetic isotope effect study and transition state analysis of the S-adenosylmethionine synthetase reaction.

Medicine & Life Sciences

• Methionine Adenosyltransferase 100%
• Isotopes 66%
• Kinetics 44%
• Adenosine Triphosphate 41%
• Methionine 32%
• Catalysis 27%
• Selenomethionine 23%
• Carbon 22%
• Sulfur 18%
• Sulfur Isotopes 16%
• methionine methyl ester 12%
• Monovalent Cations 11%
• Polyphosphates 10%
• Tritium 10%
• S-Adenosylmethionine 10%
• triphosphoric acid 9%
• Escherichia coli 5%

Chemical Compounds

• Kinetic Isotope Effect 67%
• Isotope Effect 62%
• Transition State 50%
• Methionine 31%
• Selenomethionine 21%
• Vmax 16%
• Catalysis 14%
• Carbon Atom 10%
• L-Methionine 10%
• Transition State Structure 9%
• Sulfonium 9%
• Monoatomic Monocation 9%
• Polyphosphate 8%
• Tritium 8%
• Enzymatic Reaction 7%
• Methyl Group 6%
• Biosynthesis 6%
• Displacement 6%
• Substitution Reaction 4%
• Reaction Yield 3%