A kin I-dependent Pacman-flux mechanism for anaphase A

David J. Sharp, Gregory C. Rogers

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Anaphase A chromatid-to-pole motion is fundamental for proper chromosome segregation in most systems. During the past several decades, two models for the mechanism of anaphase A have come to prominence. The Pacman model posits that chromatids induce the depolymerization of microtubule plus-ends embedded in kinetochores, thereby 'chewing' their way poleward. Alternatively, the Poleward-flux model posits that chromatids are 'reeled-in' to poles by the continual depolymerization of the minus-ends of kinetochore-associated microtubules, which are focused at spindle poles. In a recent study, we reported that anaphase A in Drosophila requires the depolymerization of both ends of kinetochore-associated microtubules, simultaneously. This is driven by two members of the Kin I subfamily of kinesins, termed KLP59C and KLP10A, which target specifically to chromatids and spindle poles, respectively. We have termed this hybrid of Pacman and Poleward flux the Kin I-dependent Pacman-flux mechanism for anaphase A. Here, we discuss the implications of these findings and explore potential additional components required to drive chromatid-to-pole motion by such a mechanism.

Original languageEnglish (US)
Pages (from-to)707-710
Number of pages4
JournalCell Cycle
Volume3
Issue number6
Publication statusPublished - Jun 2004

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Keywords

  • Anaphase A
  • Kin I kinesins
  • Microtubule
  • Mitosis
  • Mitotic spindle

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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