TY - JOUR
T1 - A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA
AU - Lieber, T.
AU - Angerer, L. M.
AU - Angerer, R. C.
AU - Childs, G.
PY - 1988
Y1 - 1988
N2 - Typical histone genes lack intervening sequences and encode small mRNAs (400-800 nucleotides) with short leader and trailer regions. Most histone mRNAs are not polyadenylated but rather terminate in a highly conserved stem and loop structure. The early, late, and testis-specific histone genes of sea urchins, described to date, have this typical histone gene structure. We have identified an unusual H1 gene, H1-δ, in sea urchins that encodes a poly(A)+ mRNA. This mRNA is one of a group of polyadenylated transcripts homologous with H1 gene probes. The sequence of H1-δ has been determined. H1-δ encodes a different H1 protein. Although the temporal expression of H1-δ mRNA is similar to that of other late H1 (β and γ) mRNAs, its spatial distribution at the time of maximal accumulation is distinct and confirms that H1-δ is regulated differently than other H1 genes.
AB - Typical histone genes lack intervening sequences and encode small mRNAs (400-800 nucleotides) with short leader and trailer regions. Most histone mRNAs are not polyadenylated but rather terminate in a highly conserved stem and loop structure. The early, late, and testis-specific histone genes of sea urchins, described to date, have this typical histone gene structure. We have identified an unusual H1 gene, H1-δ, in sea urchins that encodes a poly(A)+ mRNA. This mRNA is one of a group of polyadenylated transcripts homologous with H1 gene probes. The sequence of H1-δ has been determined. H1-δ encodes a different H1 protein. Although the temporal expression of H1-δ mRNA is similar to that of other late H1 (β and γ) mRNAs, its spatial distribution at the time of maximal accumulation is distinct and confirms that H1-δ is regulated differently than other H1 genes.
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U2 - 10.1073/pnas.85.12.4123
DO - 10.1073/pnas.85.12.4123
M3 - Article
C2 - 2898141
AN - SCOPUS:0023695307
SN - 0027-8424
VL - 85
SP - 4123
EP - 4127
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 12
ER -