A guide to fragile sites on human chromosomes

Frederick Hecht, K. H. Ramesh, David H. Lockwood

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

This is a guide to 107 fragile sites, all those considered at the most recent International Workshop on Human Gene Mapping, HGM 9.5, held in 1988. The chromosome band locations of all 107 fragile sites are given, together with their gene symbols, frequency, mode of induction, and status. The majority of these fragile sites are common ones induced to expression by aphidicolin. Fragile sites are nonrandomly distributed within the genome. Chromosome 3 is especially short of known fragile sites. Chromosome 21, the chromosome triplicated in Down syndrome, has no known fragile sites.

Original languageEnglish (US)
Pages (from-to)37-45
Number of pages9
JournalCancer Genetics and Cytogenetics
Volume44
Issue number1
DOIs
StatePublished - Jan 1990
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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