@article{bbb6185a23934b968a5a747882a8d614,
title = "A genome-wide association study in hispanics/latinos identifies novel signals for lung function the hispanic community health study/study of latinos",
abstract = "Rationale: Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Genome-wide association studies (GWAS) have identified numerous pulmonary function and COPD loci, primarily in cohorts of European ancestry. Objectives: Perform a GWAS of COPD phenotypes in Hispanic/Latino populations to identify loci not previously detected in European populations. Methods: GWAS of lung function and COPD in Hispanic/Latino participants from a population-based cohort. We performed replication studies of novel loci in independent studies. Measurements and Main Results: Among 11,822 Hispanic/Latino participants, we identified eight novel signals; three replicated in independent populations of European Ancestry. A novel locus for FEV1 in ZSWIM7 (rs4791658; P = 4.99 3 1029) replicated. A rare variant (minor allele frequency = 0.002) in HAL (rs145174011) was associated with FEV1/FVC (P = 9.59 3 1029) in a region previously identified for COPD-related phenotypes; it remained significant in conditional analyses but did not replicate. Admixture mapping identified a novel region, with a variant in AGMO (rs41331850), associated with Amerindian ancestry and FEV1, which replicated. A novel locus for FEV1 identified among ever smokers (rs291231; P = 1.92 3 1028) approached statistical significance for replication in admixed populations of African ancestry, and a novel SNP for COPD in PDZD2 (rs7709630; P = 1.56 3 1028) regionally replicated. In addition, loci previously identified for lung function in European samples were associated in Hispanic/Latino participants in the Hispanic Community Health Study/Study of Latinos at the genome-wide significance level. Conclusions: We identified novel signals for lung function and COPD in a Hispanic/Latino cohort. Including admixed populations when performing genetic studies may identify variants contributing to genetic etiologies of COPD.",
keywords = "Chronic bstructive pulmonary disease, Genome-wide association study, Hispanic/Latino, Ingle-nucleotide polymorphisms, Lung function",
author = "Burkart, {Kristin M.} and Tamar Sofer and London, {Stephanie J.} and Ani Manichaikul and Hartwig, {Fernando P.} and Qi Yan and Artigas, {Mar{\'i}a Soler} and Lydiana Avila and Wei Chen and Thomas, {Sonia Davis} and Diaz, {Alejandro A.} and Hall, {Ian P.} and Horta, {Bernardo L.} and Kaplan, {Robert C.} and Laurie, {Cathy C.} and Menezes, {Ana M.} and Morrison, {Jean V.} and Oelsner, {Elizabeth C.} and Deepa Rastogi and Rich, {Stephen S.} and Manuel Soto-Quiros and Stilp, {Adrienne M.} and Tobin, {Martin D.} and Wain, {Louise V.} and Celed{\'o}n, {Juan C.} and {Graham Barr}, R.",
note = "Funding Information: The authors thank the investigators, participants, and staff of the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) for their contributions to this study. The HCHS/SOL investigators thank the NHLBI and the research institutions, study investigators, and field staff for their support in creating this study. They also thank the study participants, without whom this endeavor would not have been possible. Funding Information: The baseline examination of HCHS/SOL (Hispanic Community Health Study/Study of Latinos) was performed as a collaborative study supported by NHLBI contracts N01-HC65233 (University of North Carolina), N01-HC65234 (University of Miami), N01-HC65235 (Albert Einstein College of Medicine), N01-HC65236 (Northwestern University), and N01-HC65237 (San Diego State University). The following institutes, centers, and offices contributed to the first phase of HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Neurological Disorders and Stroke, and NIH Office of Dietary Supplements. The Genetic Analysis Center at the University of Washington was supported by NHLBI and NIDCR contracts HHSN268201300005C AM03 and MOD03. Additional analysis support was provided by NIDDK grant 1R01DK101855-01 and American Heart Association grant 13GRNT16490017. Genotyping efforts were supported by the NIH Department of Health and Human Services grant HSN26220/20054C, National Center for Advancing Translational Science/Clinical Translational Science Institute grant UL1TR000124, and NIDDK Diabetes Research Center grant DK063491. This manuscript has been reviewed by the HCHS/SOL Publications Committee for scientific content and consistency of data interpretation with previous HCHS/SOL publications. T.S. is supported by NHLBI grant 1R35HL135818. A.A.D. is supported by NIH/NHLBI grant K01HL118714 and the Brigham and Women{\textquoteright}s Hospital Minority Faculty Career Development Award. S.J.L. is supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences. R.G.B. is supported by NIH/NHLBI grants R01-HL077612 and R01-HL093081. For funding information for COPD-Costa Rica, MESA Lung, 1982 Pelotas Birth Cohort Study, and SpiroMeta, see the online supplement. Publisher Copyright: Copyright {\textcopyright} 2018 by the American Thoracic Society.",
year = "2018",
month = jul,
day = "15",
doi = "10.1164/rccm.201707-1493OC",
language = "English (US)",
volume = "198",
pages = "208--219",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "2",
}