A fleeting glimpse inside microRNA, epigenetics, and micropeptidomics

Gaetano Santulli

5 Scopus citations

Abstract

MicroRNAs (miRs) are important regulators of gene expression in numerous biological processes. Their maturation process is herein described, including the most updated insights from the current literature. Circa 2000 miR sequences have been identified in the human genome, with over 50,000 miR-target interactions, including enzymes involved in epigenetic modulation of gene expression. Moreover, some “pieces of RNA” previously annotated as noncoding have been recently found to encode micropeptides that carry out critical mechanistic functions in the cell. Advanced techniques now available will certainly allow a precise scanning of the genome looking for micropeptides hidden within the “noncoding” RNA.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages1-14
Number of pages14
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume887
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • Dicer
  • Drosha
  • EpimiR
  • Exportin
  • Humanin
  • METTL3
  • Micropeptides
  • Micropeptidome
  • Micropeptidomics
  • miRBase
  • miRNA
  • miRWalk
  • Mitochondria Myogenin
  • MOTS-c
  • ORF
  • Pharmacogenomics
  • Precision medicine
  • RISC
  • SERCA
  • TargetScan
  • Transcriptome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Santulli, G. (2015). A fleeting glimpse inside microRNA, epigenetics, and micropeptidomics. In Advances in Experimental Medicine and Biology (pp. 1-14). (Advances in Experimental Medicine and Biology; Vol. 887). Springer New York LLC. https://doi.org/10.1007/978-3-319-22380-3_1