TY - JOUR
T1 - A clinical and pathologic comparison between stage-matched endometrial intraepithelial carcinoma and uterine serous carcinoma
T2 - Is there a difference?
AU - Hou, June Y.
AU - McAndrew, Thomas C.
AU - Goldberg, Gary L.
AU - Whitney, Kathleen
AU - Shahabi, Shohreh
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Dr. June Hou is partially supported by the Calabresi Career Development Grant at Albert Einstein Cancer Center , via the National Cancer Institute , Mentored Clinical Scientist Development Award Program, grant # CA077263 .
PY - 2014/4
Y1 - 2014/4
N2 - Endometrial intraepithelial carcinoma (EIC) is a rare pathologic variant of uterine serous carcinoma (USC). Our aim is to distinguish patterns of clinic-pathologic outcomes in patients with EIC and USC for disease limited to the endometrium (stage 1A) as well as with distant metastasis (stage 4B). Surgically staged patients were retrospectively identified and relevant variables were extracted and compared. Kaplan-Meier was used to generate the survival data. More USC (n = 29) exhibited lymphovascular invasion (stage 4, P =.01) and expressed higher levels of estrogen receptor-α than EIC (P =.0009 and.063 for stages 1 and 4, respectively). The survival is comparable, with 1 recurrence in each group for stage 1A disease. For stage 4 EIC and USC, the progression-free survival (14 vs10 months) and overall survival (19 vs 20 months) are similar to what is previously published. In conclusion, EIC, whether limited to the endometrium, or widely metastatic, imparts similar outcomes and should be treated comparably with stage-matched USC.
AB - Endometrial intraepithelial carcinoma (EIC) is a rare pathologic variant of uterine serous carcinoma (USC). Our aim is to distinguish patterns of clinic-pathologic outcomes in patients with EIC and USC for disease limited to the endometrium (stage 1A) as well as with distant metastasis (stage 4B). Surgically staged patients were retrospectively identified and relevant variables were extracted and compared. Kaplan-Meier was used to generate the survival data. More USC (n = 29) exhibited lymphovascular invasion (stage 4, P =.01) and expressed higher levels of estrogen receptor-α than EIC (P =.0009 and.063 for stages 1 and 4, respectively). The survival is comparable, with 1 recurrence in each group for stage 1A disease. For stage 4 EIC and USC, the progression-free survival (14 vs10 months) and overall survival (19 vs 20 months) are similar to what is previously published. In conclusion, EIC, whether limited to the endometrium, or widely metastatic, imparts similar outcomes and should be treated comparably with stage-matched USC.
KW - EIC
KW - USC
KW - serous intraepithelial carcinoma
KW - uterine serous carcinoma
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U2 - 10.1177/1933719113503414
DO - 10.1177/1933719113503414
M3 - Article
C2 - 24023030
AN - SCOPUS:84898986418
SN - 1933-7191
VL - 21
SP - 532
EP - 537
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 4
ER -