A clinical and pathologic comparison between stage-matched endometrial intraepithelial carcinoma and uterine serous carcinoma: Is there a difference?

June Y. Hou, Thomas C. McAndrew, Gary L. Goldberg, Kathleen Whitney, Shohreh Shahabi

Research output: Contribution to journalArticle

4 Scopus citations


Endometrial intraepithelial carcinoma (EIC) is a rare pathologic variant of uterine serous carcinoma (USC). Our aim is to distinguish patterns of clinic-pathologic outcomes in patients with EIC and USC for disease limited to the endometrium (stage 1A) as well as with distant metastasis (stage 4B). Surgically staged patients were retrospectively identified and relevant variables were extracted and compared. Kaplan-Meier was used to generate the survival data. More USC (n = 29) exhibited lymphovascular invasion (stage 4, P =.01) and expressed higher levels of estrogen receptor-α than EIC (P =.0009 and.063 for stages 1 and 4, respectively). The survival is comparable, with 1 recurrence in each group for stage 1A disease. For stage 4 EIC and USC, the progression-free survival (14 vs10 months) and overall survival (19 vs 20 months) are similar to what is previously published. In conclusion, EIC, whether limited to the endometrium, or widely metastatic, imparts similar outcomes and should be treated comparably with stage-matched USC.

Original languageEnglish (US)
Pages (from-to)532-537
Number of pages6
JournalReproductive Sciences
Issue number4
Publication statusPublished - Apr 2014



  • EIC
  • USC
  • serous intraepithelial carcinoma
  • uterine serous carcinoma

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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