A BMI >35 does not protect patients undergoing cardiac bypass surgery from red blood cell transfusion

Linda B. Mongero, Eric A. Tesdahl, Al H. Stammers, Timothy A. Dickinson, Alan P. Kypson, John Brown, Sam Weinstein

Research output: Research - peer-reviewArticle

Abstract

The effect of obesity on allogeneic intraoperative blood product transfusion in patients undergoing coronary artery bypass graft surgery (CABG) is poorly understood. We analyzed the influence of obesity on the risk of intraoperative red blood cell (RBC) transfusion among 45,200 consecutive non-reoperative CABG procedures from a multi-institutional perfusion database. A body mass index (BMI) in obese I category was associated with a 9.9% decrease in transfusion risk (p<0.05). Compared to patients with a normal BMI, obese I and obese III patients do not have any change in the relative risk of RBC transfusion. Overweight and mild obesity have a protective role in reducing intraoperative blood transfusion during cardiopulmonary bypass (CPB) surgery. However, logistic regression analysis showed that much of the observed reduction in transfusion rates for obese patients can be accounted for by other known confounds. The lack of a linear effect of increasing BMI on blood transfusion risk is a novel finding and warrants further investigation.

LanguageEnglish (US)
Pages20-26
Number of pages7
JournalPerfusion
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Erythrocyte Transfusion
Thoracic Surgery
Body Mass Index
Surgery
Blood
Cells
surgery
Blood Transfusion
Obesity
Coronary Artery Bypass
Transplants
Grafts
Cardiopulmonary Bypass
Perfusion
Logistic Models
Regression Analysis
Databases
regression analysis
logistics
lack

Keywords

  • BMI >35
  • cardiac surgery
  • cardiopulmonary bypass
  • obesity
  • obesity paradox
  • red blood cell transfusions

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Safety Research
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Mongero, L. B., Tesdahl, E. A., Stammers, A. H., Dickinson, T. A., Kypson, A. P., Brown, J., & Weinstein, S. (2017). A BMI >35 does not protect patients undergoing cardiac bypass surgery from red blood cell transfusion. Perfusion, 32(1), 20-26. DOI: 10.1177/0267659116652213

A BMI >35 does not protect patients undergoing cardiac bypass surgery from red blood cell transfusion. / Mongero, Linda B.; Tesdahl, Eric A.; Stammers, Al H.; Dickinson, Timothy A.; Kypson, Alan P.; Brown, John; Weinstein, Sam.

In: Perfusion, Vol. 32, No. 1, 01.01.2017, p. 20-26.

Research output: Research - peer-reviewArticle

Mongero, LB, Tesdahl, EA, Stammers, AH, Dickinson, TA, Kypson, AP, Brown, J & Weinstein, S 2017, 'A BMI >35 does not protect patients undergoing cardiac bypass surgery from red blood cell transfusion' Perfusion, vol 32, no. 1, pp. 20-26. DOI: 10.1177/0267659116652213
Mongero LB, Tesdahl EA, Stammers AH, Dickinson TA, Kypson AP, Brown J et al. A BMI >35 does not protect patients undergoing cardiac bypass surgery from red blood cell transfusion. Perfusion. 2017 Jan 1;32(1):20-26. Available from, DOI: 10.1177/0267659116652213
Mongero, Linda B. ; Tesdahl, Eric A. ; Stammers, Al H. ; Dickinson, Timothy A. ; Kypson, Alan P. ; Brown, John ; Weinstein, Sam. / A BMI >35 does not protect patients undergoing cardiac bypass surgery from red blood cell transfusion. In: Perfusion. 2017 ; Vol. 32, No. 1. pp. 20-26
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