A basis for fluoropyrimidine induced antagonism to methotrexate in Ehrlich ascites tumor cells in vitro

D. Bowen, J. C. White, I. David Goldman

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The inhibitory effect of methotrexate on [3H]deoxyuridine incorporation into DNA is reduced as the basal rate of this reaction is inhibited by pretreatment of Ehrlich ascites tumor cells with fluoropyrimidines. This observation is a basis for fluoropyrimidine-methotrexate antagonism in anticancer regimens and supports the concept that the sensitivity of thymidylate synthesis in tumor cells to methotrexate is related, in part, to the basal rate of thymidylate synthesis from deoxyuridylate.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalCancer Research
Volume38
Issue number1
StatePublished - 1978
Externally publishedYes

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Ehrlich Tumor Carcinoma
Methotrexate
Deoxyuridine
DNA
In Vitro Techniques
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

A basis for fluoropyrimidine induced antagonism to methotrexate in Ehrlich ascites tumor cells in vitro. / Bowen, D.; White, J. C.; Goldman, I. David.

In: Cancer Research, Vol. 38, No. 1, 1978, p. 219-222.

Research output: Contribution to journalArticle

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