The inhibitory effect of methotrexate on [3 H]deoxyuridine incorporation into DNA is reduced as the basal rate of this reaction is inhibited by pretreatment of Ehrlich ascites tumor cells with fluoropyrimidines. This observation is a basis for fluoropyrimidine-methotrexate antagonism in anticancer regimens and supports the concept that the sensitivity of thymidylate synthesis in tumor cells to methotrexate is related, in part, to the basal rate of thymidylate synthesis from deoxyuridylate.
|Original language||English (US)|
|Number of pages||4|
|Publication status||Published - Jan 1978|
ASJC Scopus subject areas
- Cancer Research