TY - JOUR
T1 - 3D MRI of whole-brain water permeability with intrinsic diffusivity encoding of arterial labeled spin (IDEALS)
AU - Wengler, Kenneth
AU - Bangiyev, Lev
AU - Canli, Turhan
AU - Duong, Tim Q.
AU - Schweitzer, Mark E.
AU - He, Xiang
N1 - Funding Information:
The authors thank Stony Brook University Departments of Radiology, Psychology, and Psychiatry for providing pilot grant funding for this study. Special thanks are given to Dr. Danny JJ Wang from University of Southern California for discussion and inspiration. Special thanks are given to Dr. Christine DeLorenzo for interest and discussion. Thanks to Ms. Andrea He from UC Berkeley for careful review of the manuscript. This work was partly supported by a Research Scholar grant from Radiological Society of North America (RSNA) R&E Foundation .
Funding Information:
The authors thank Stony Brook University Departments of Radiology, Psychology, and Psychiatry for providing pilot grant funding for this study. Special thanks are given to Dr. Danny JJ Wang from University of Southern California for discussion and inspiration. Special thanks are given to Dr. Christine DeLorenzo for interest and discussion. Thanks to Ms. Andrea He from UC Berkeley for careful review of the manuscript. This work was partly supported by a Research Scholar grant from Radiological Society of North America (RSNA) R&E Foundation.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - This work proposes a novel MRI method – Intrinsic Diffusivity Encoding of Arterial Labeled Spin (IDEALS) – for the whole-brain mapping of water permeability in the human brain without an exogenous contrast agent. Quantitative separation of the intravascular and extravascular labeled water MRI signal was achieved in arterial spin labeling experiments with segmented 3D-GRASE acquisition by modulating the relative sensitivity between relaxation, true diffusion, and pseudodiffusion. The intrinsic diffusivity encoding in k-space created different broadening of the image-domain point spread functions for intravascular and extravascular labeled spins, from which blood-brain barrier (BBB) water extraction fraction (E w ) and water permeability surface area product (PS w ) were estimated. The feasibility and sensitivity of this method was evaluated in healthy subjects at baseline and after caffeine challenge. The estimated baseline E w and PS w maps showed contrast among gray matter (GM) and white matter (WM). GM E w was significantly lower than that of WM (78.8% ± 3.3% in GM vs. 83.9% ± 4.6% in WM; p < 0.05) and GM PS w was significantly higher than that of WM (131.7 ± 29.5 mL/100 g/min in GM vs. 76.2 ± 18.4 mL/100 g/min in WM; p < 0.05). BBB E w was significantly lower for females than males (74.9% ± 3.7% for females vs. 81.3% ± 3.3% for males in GM; 80.5% ± 4.7% for females vs. 86.1 ± 3.0 for males in WM; p < 0.05 for both), while significant PS w differences were only observed in WM (143.8 ± 34.4 mL/100 g/min for females vs. 123.6 ± 24.4 mL/100 g/min for males in GM; 91.6 ± 15.0 mL/100 g/min for females vs. 65.9 ± 12.5 mL/100 g/min for males in WM; p = 0.20 and p < 0.05 for GM and WM respectively). Significant correlations between E w and CBF (r = −0.32, p < 0.05) and between PS w and CBF (r = 0.89, p < 0.05) were observed, consistent with 15 O-H 2 O PET findings. After caffeine challenge, reduced CBF, E w and PS w were observed, demonstrating the sensitivity of IDEALS approach.
AB - This work proposes a novel MRI method – Intrinsic Diffusivity Encoding of Arterial Labeled Spin (IDEALS) – for the whole-brain mapping of water permeability in the human brain without an exogenous contrast agent. Quantitative separation of the intravascular and extravascular labeled water MRI signal was achieved in arterial spin labeling experiments with segmented 3D-GRASE acquisition by modulating the relative sensitivity between relaxation, true diffusion, and pseudodiffusion. The intrinsic diffusivity encoding in k-space created different broadening of the image-domain point spread functions for intravascular and extravascular labeled spins, from which blood-brain barrier (BBB) water extraction fraction (E w ) and water permeability surface area product (PS w ) were estimated. The feasibility and sensitivity of this method was evaluated in healthy subjects at baseline and after caffeine challenge. The estimated baseline E w and PS w maps showed contrast among gray matter (GM) and white matter (WM). GM E w was significantly lower than that of WM (78.8% ± 3.3% in GM vs. 83.9% ± 4.6% in WM; p < 0.05) and GM PS w was significantly higher than that of WM (131.7 ± 29.5 mL/100 g/min in GM vs. 76.2 ± 18.4 mL/100 g/min in WM; p < 0.05). BBB E w was significantly lower for females than males (74.9% ± 3.7% for females vs. 81.3% ± 3.3% for males in GM; 80.5% ± 4.7% for females vs. 86.1 ± 3.0 for males in WM; p < 0.05 for both), while significant PS w differences were only observed in WM (143.8 ± 34.4 mL/100 g/min for females vs. 123.6 ± 24.4 mL/100 g/min for males in GM; 91.6 ± 15.0 mL/100 g/min for females vs. 65.9 ± 12.5 mL/100 g/min for males in WM; p = 0.20 and p < 0.05 for GM and WM respectively). Significant correlations between E w and CBF (r = −0.32, p < 0.05) and between PS w and CBF (r = 0.89, p < 0.05) were observed, consistent with 15 O-H 2 O PET findings. After caffeine challenge, reduced CBF, E w and PS w were observed, demonstrating the sensitivity of IDEALS approach.
KW - Arterial spin labeling
KW - BBB water permeability surface area product
KW - Blood-brain barrier (BBB) water extraction fraction
KW - Deconvolution
KW - Point spread function
KW - Segmented 3D-GRASE
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UR - http://www.scopus.com/inward/citedby.url?scp=85060520048&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2019.01.035
DO - 10.1016/j.neuroimage.2019.01.035
M3 - Article
C2 - 30682535
AN - SCOPUS:85060520048
SN - 1053-8119
VL - 189
SP - 401
EP - 414
JO - NeuroImage
JF - NeuroImage
ER -
