3-nitropropionic acid as a tool to study the mechanisms involved in huntington's disease: Past, present and future

Isaac Túnez, Inmaculada Tasset, Verónica Pérez De La Cruz, Abel Santamaría

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

Huntington's disease (HD) is an inheritable autosomal-dominant disorder whose causal mechanisms remain unknown. Experimental models have begun to uncover these pathways, thus helping to understand the mechanisms implicated and allowing for the characterization of potential targets for new therapeutic strategies. 3-Nitropropionic acid is known to produce in animals behavioural, biochemical and morphologic changes similar to those occurring in HD. For this reason, this phenotypic model is gaining attention as a valuable tool to mimick this disorder and further developing new therapies. In this review, we will focus on the past and present research of this molecule, to finally bring a perspective on what will be next in this promising field of study.

Original languageEnglish (US)
Pages (from-to)878-916
Number of pages39
JournalMolecules
Volume15
Issue number2
DOIs
StatePublished - Feb 2010
Externally publishedYes

Keywords

  • 3-nitropropionic acid
  • Huntington's disease
  • Quinolinic acid
  • Succinate dehydrogenase
  • Transgenic mice models

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of '3-nitropropionic acid as a tool to study the mechanisms involved in huntington's disease: Past, present and future'. Together they form a unique fingerprint.

  • Cite this