1′-Acetoxychavicol acetate induces apoptosis of myeloma cells via induction of TRAIL

Keisuke Ito, Tomonori Nakazato, Akira Murakami, Hajime Ohigashi, Yasuo Ikeda, Masahiro Kizaki

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A component of a traditional Thai condiment, 1′-acetoxychavicol acetate (ACA), is a natural compound, and it is obtained from rhizomes of the ethno-medicinal plant Languas galanga (Zingiberaceae). Our previous studies showed that ACA dramatically inhibited cellular growth of multiple myeloma cells in vivo and in vitro through the induction of apoptosis in association with the activation of caspase-8, inactivation of NF-κB, and down-regulation of anti-apoptotic proteins. Subsequently, we investigated the detailed apoptotic pathway of ACA and further demonstrated that ACA up-regulates the expression of both TNF-related apoptosis-inducing ligand/Apo2 ligand (TRAIL/Apo2L) and TRAIL receptor death receptor 5 (DR5). In addition, TRAIL/R-Fc chimera neutralizes the ACA-induced apoptosis. These results suggest that the death signaling of TRAIL is involved in the ACA-induced apoptosis of myeloma cells, and provide a rationale for the induction of TRAIL/Apo2L by ACA, which could potentially be used as a novel therapeutic agent in patients with multiple myeloma.

Original languageEnglish (US)
Pages (from-to)1702-1710
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume338
Issue number4
DOIs
Publication statusPublished - Dec 30 2005
Externally publishedYes

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Keywords

  • 1′-Acetoxychavicol acetate
  • Apoptosis
  • Multiple myeloma
  • TRAIL

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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