Δ9-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex

Chen Jianping, William Paredes, Joyce H. Lowinson, Eliot L. Gardner

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

Acute administration of 1.0-2.0 mg/kg Δ9-tetrahydrocannabinoI Δ9-THC) increased presynaptic dopamine (DA) efflux in the medial prefrontal cortex of rats, as measured by intracerebral microdialysis in awake, behaving rats. These data are congruent with suggestions that (1) marijuana's euphorigenic effects and abuse potential may be related to augmentation of presynaptic DA mechanisms, and (2) the medial prefrontal cortex may be an important site of action for drugs of abuse in general and for Δ9-THC in particular.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalEuropean Journal of Pharmacology
Volume190
Issue number1-2
DOIs
StatePublished - Nov 6 1990

Keywords

  • Cortex (medial prefrontal)
  • Dopamine
  • Drugs of abuse
  • Marijuana
  • Microdialysis
  • Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

  • Pharmacology

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