Δ9-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex

Chen Jianping, William Paredes, Joyce H. Lowinson, Eliot L. Gardner

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Acute administration of 1.0-2.0 mg/kg Δ9-tetrahydrocannabinoI Δ9-THC) increased presynaptic dopamine (DA) efflux in the medial prefrontal cortex of rats, as measured by intracerebral microdialysis in awake, behaving rats. These data are congruent with suggestions that (1) marijuana's euphorigenic effects and abuse potential may be related to augmentation of presynaptic DA mechanisms, and (2) the medial prefrontal cortex may be an important site of action for drugs of abuse in general and for Δ9-THC in particular.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalEuropean Journal of Pharmacology
Volume190
Issue number1-2
DOIs
StatePublished - Nov 6 1990

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Dronabinol
Prefrontal Cortex
Dopamine
Microdialysis
Street Drugs
Cannabis

Keywords

  • Cortex (medial prefrontal)
  • Dopamine
  • Drugs of abuse
  • Marijuana
  • Microdialysis
  • Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Δ9-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex. / Jianping, Chen; Paredes, William; Lowinson, Joyce H.; Gardner, Eliot L.

In: European Journal of Pharmacology, Vol. 190, No. 1-2, 06.11.1990, p. 259-262.

Research output: Contribution to journalArticle

Jianping, Chen ; Paredes, William ; Lowinson, Joyce H. ; Gardner, Eliot L. / Δ9-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex. In: European Journal of Pharmacology. 1990 ; Vol. 190, No. 1-2. pp. 259-262.
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