γ Chain-associated cytokine receptors signal through distinct transducing factors

A. Pernis, S. Gupta, J. Yopp, Evan S. Garfein, H. Kashleva, C. Schindler, P. Rothman

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand- specific binding chains that associate with a shared signaling subunit, the common γ (γ(c)) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γ(c)-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.

Original languageEnglish (US)
Pages (from-to)14517-14522
Number of pages6
JournalJournal of Biological Chemistry
Volume270
Issue number24
DOIs
StatePublished - 1995
Externally publishedYes

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Cytokine Receptors
Interleukin-7
Interleukin-4
Interleukin-2
Interleukin-7 Receptors
Ligands
Protein-Tyrosine Kinases
Chemical activation
Cytokines
Molecules
Proteins

ASJC Scopus subject areas

  • Biochemistry

Cite this

γ Chain-associated cytokine receptors signal through distinct transducing factors. / Pernis, A.; Gupta, S.; Yopp, J.; Garfein, Evan S.; Kashleva, H.; Schindler, C.; Rothman, P.

In: Journal of Biological Chemistry, Vol. 270, No. 24, 1995, p. 14517-14522.

Research output: Contribution to journalArticle

Pernis, A, Gupta, S, Yopp, J, Garfein, ES, Kashleva, H, Schindler, C & Rothman, P 1995, 'γ Chain-associated cytokine receptors signal through distinct transducing factors', Journal of Biological Chemistry, vol. 270, no. 24, pp. 14517-14522. https://doi.org/10.1074/jbc.270.24.14517
Pernis, A. ; Gupta, S. ; Yopp, J. ; Garfein, Evan S. ; Kashleva, H. ; Schindler, C. ; Rothman, P. / γ Chain-associated cytokine receptors signal through distinct transducing factors. In: Journal of Biological Chemistry. 1995 ; Vol. 270, No. 24. pp. 14517-14522.
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AU - Gupta, S.

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AU - Schindler, C.

AU - Rothman, P.

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