Abstract
The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand- specific binding chains that associate with a shared signaling subunit, the common γ (γ(c)) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γ(c)-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 14517-14522 |
| Number of pages | 6 |
| Journal | Journal of Biological Chemistry |
| Volume | 270 |
| Issue number | 24 |
| DOIs | |
| State | Published - 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
Cite this
γ Chain-associated cytokine receptors signal through distinct transducing factors. / Pernis, A.; Gupta, S.; Yopp, J.; Garfein, Evan S.; Kashleva, H.; Schindler, C.; Rothman, P.
In: Journal of Biological Chemistry, Vol. 270, No. 24, 1995, p. 14517-14522.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - γ Chain-associated cytokine receptors signal through distinct transducing factors
AU - Pernis, A.
AU - Gupta, S.
AU - Yopp, J.
AU - Garfein, Evan S.
AU - Kashleva, H.
AU - Schindler, C.
AU - Rothman, P.
PY - 1995
Y1 - 1995
N2 - The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand- specific binding chains that associate with a shared signaling subunit, the common γ (γ(c)) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γ(c)-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.
AB - The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand- specific binding chains that associate with a shared signaling subunit, the common γ (γ(c)) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γ(c)-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.
UR - http://www.scopus.com/inward/record.url?scp=0029031756&partnerID=8YFLogxK
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U2 - 10.1074/jbc.270.24.14517
DO - 10.1074/jbc.270.24.14517
M3 - Article
VL - 270
SP - 14517
EP - 14522
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 24
ER -