TY - JOUR
T1 - γ Chain-associated cytokine receptors signal through distinct transducing factors
AU - Pernis, A.
AU - Gupta, S.
AU - Yopp, J.
AU - Garfein, E.
AU - Kashleva, H.
AU - Schindler, C.
AU - Rothman, P.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand- specific binding chains that associate with a shared signaling subunit, the common γ (γ(c)) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γ(c)-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.
AB - The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand- specific binding chains that associate with a shared signaling subunit, the common γ (γ(c)) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γ(c)-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.
UR - http://www.scopus.com/inward/record.url?scp=0029031756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029031756&partnerID=8YFLogxK
U2 - 10.1074/jbc.270.24.14517
DO - 10.1074/jbc.270.24.14517
M3 - Article
C2 - 7782314
AN - SCOPUS:0029031756
VL - 270
SP - 14517
EP - 14522
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 24
ER -