γ Chain-associated cytokine receptors signal through distinct transducing factors

A. Pernis, S. Gupta, J. Yopp, E. Garfein, H. Kashleva, C. Schindler, P. Rothman

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29 Scopus citations

Abstract

The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand- specific binding chains that associate with a shared signaling subunit, the common γ (γ(c)) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γ(c)-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.

Original languageEnglish (US)
Pages (from-to)14517-14522
Number of pages6
JournalJournal of Biological Chemistry
Volume270
Issue number24
DOIs
StatePublished - Jan 1 1995

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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