β2-Microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium

Steven P. Balk, Steven Burke, John E. Polischuk, Martha E. Frantz, Lin Yang, Steven A. Porcelli, Sean P. Colgan, Richard S. Blumberg

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

A major histocompatibility complex class Ib protein, CD1d, is expressed by human intestinal epithelial cells (IECs) and is a ligand for CD8+ T cells. CD1d was found to be expressed on the surface of human IECs as a 37- kilodalton protein that was β2-microglobulin (β2M) independent with no N- linked carbohydrate. Transfection into a β2M- cell line confirmed that CD1d could be expressed at the cell surface in the absence of β2M. These data indicate that IECs use a specialized pathway for CD1d synthesis and that a β2M-independent class Ib protein may be the normal ligand for some intestinal T cells.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalScience
Volume265
Issue number5169
StatePublished - Jul 8 1994
Externally publishedYes

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Intestinal Mucosa
Epithelial Cells
Ligands
T-Lymphocytes
Proteins
Major Histocompatibility Complex
Transfection
Carbohydrates
Cell Line

ASJC Scopus subject areas

  • General

Cite this

Balk, S. P., Burke, S., Polischuk, J. E., Frantz, M. E., Yang, L., Porcelli, S. A., ... Blumberg, R. S. (1994). β2-Microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science, 265(5169), 259-262.

β2-Microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. / Balk, Steven P.; Burke, Steven; Polischuk, John E.; Frantz, Martha E.; Yang, Lin; Porcelli, Steven A.; Colgan, Sean P.; Blumberg, Richard S.

In: Science, Vol. 265, No. 5169, 08.07.1994, p. 259-262.

Research output: Contribution to journalArticle

Balk, SP, Burke, S, Polischuk, JE, Frantz, ME, Yang, L, Porcelli, SA, Colgan, SP & Blumberg, RS 1994, 'β2-Microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium', Science, vol. 265, no. 5169, pp. 259-262.
Balk SP, Burke S, Polischuk JE, Frantz ME, Yang L, Porcelli SA et al. β2-Microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science. 1994 Jul 8;265(5169):259-262.
Balk, Steven P. ; Burke, Steven ; Polischuk, John E. ; Frantz, Martha E. ; Yang, Lin ; Porcelli, Steven A. ; Colgan, Sean P. ; Blumberg, Richard S. / β2-Microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. In: Science. 1994 ; Vol. 265, No. 5169. pp. 259-262.
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