Surfactant-vesicle based gonorrhea vaccine

Project: Research projectSmall Business Innovation Research Grants (SBIR) - Phase I

Description

Vaccination is the most cost-effective method for controlling and eradicating infectious diseases. Its significant impact on human health is exemplified by the eradication of smallpox and the elimination of poliomyelitis from most of the world and measles in many developed countries. With the emergence of ceftriaxone-resistant Neisseria gonorrhoeae, it is imperative that we generate a vaccine for this disease. However, generating vaccines against gonorrhea using traditional approaches has failed and novel strategies are needed. The hypothesis to be tested in this proposal is that cell surface components, incorporated into or associated with negatively-charged catanionic vesicles will reduce their toxicity while retaining their immunogenicity of these components, and that immunization with these vesicles will be capable of inducing a protective immune response. We will test this hypothesis by constructing a vaccine derived from N. gonorrhoeae, characterize the elicited immune response using general principles of vaccine quality control, and determine the safety of the vaccine and vaccine vehicle.
StatusActive
Effective start/end date8/1/187/31/19

Funding

  • National Institutes of Health: $268,434.00

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Gonorrhea
Surface-Active Agents
Vaccines
Neisseria gonorrhoeae
Smallpox
Ceftriaxone
Measles
Poliomyelitis
Cellular Structures
Developed Countries
Quality Control
Communicable Diseases
Immunization
Vaccination
Safety
Costs and Cost Analysis
Health

Keywords

  • Medicine(all)
  • Immunology and Microbiology(all)