SOLID PHASE SYNTHESIS OF PEPTIDES &PROTEINS

  • Heintz, Nathaniel (PI)
  • Cowburn, David (PI)
  • Wang, Rong (PI)
  • Burley, Stephen K. (PI)
  • Merrifield, Robert B. (PI)

Project: Research project

Project Details

Description

We are using solid Phase Synthesis to produce varied hybrid analogs of antibiotic peptides, utilizing D & L amino acids for the purpose of (I) Potentiating the antibiotic effect (II) Decreasing the susceptibility of these peptides to circulating peptidase digestion. (III) Elucidating the nature of the peptide-cell wall & peptide-peptide interactions.
StatusFinished
Effective start/end date10/1/919/30/01

Funding

  • National Center for Research Resources

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  • Natl Resource for Mass Spectrom of Biolog Macromolecules

    Chait, B. T., Abreu, I. A., Adzuma, K., Aebersold, R. H., Aitchison, J. D., Allis, C. D., Andren, P. E., Backlund, P. S., Beavis, R. C., Bern, M. W., Beyreuther, K., Birken, S., Blobel, G., Boeke, J. D., Bradley, C. C., Bradshaw, R. A., Breslow, N. J., Breslow, J. L., Burley, S. K., Burley, S., Buxbaum, J. D., Cadene, M., Campbell, E. A., Canfield, R. E., Canfield, R., Cardozo, C., Cerami, A., Chang, E. J., Chang, E. Y., Chen, E., Christea, I. M., Chua, N., Cohen, S. L., Cohen, S., Cowburn, D., Cross, G. A. M., Cross, F. R., Darnell, J. E., Darst, S. A., de Lange, T., Degrasse, J., Demmers, J., Deshaies, R. J., Dodd, J., Duff, K. E., Dutzler, R., Engelberg-Kulka, H., Eriksson, J., Fenyo, D., Fenyo, J., Field, F. H., Field, M., Fischetti, V. A., Friedman, J. M., Funabiki, H., Gadsby, D. C., Gandy, S. E., Gautier, J., Gilman, A. G., Giriat, I., Glavy, J. S., Goddard, N. L., Gotschlich, E. C., Greene, L. J., Greengard, P., Grendell, J. H., Gu, W., Hajjar, K. A., Haley, J. D., Hall, W. W., Heintz, N., Hingorani, M. M., Ho, D. D., Holford, M. N., Hudspeth, A. J., Hugli, T. E., Jacobs, E. Y., Jeruzalmi, D., Jiang, Y., Jin, M., Jin, S. V., Jordan, B., Jordan, W. B., Kaiser, N. E., Kalkum, M., Kapoor, T. M., Kato, H., Keeney, S., Kent, S., Kim, Y. I., Kipper, J., Kreek, M. J., Kretzschmar, M. D., Krutchinsky, A. N., Kufe, D. W., Kuriyan, J., Lander, H. M., Lazarow, P. B., Leonard, J., Lima, C. D., Lindsey, J., Lindsey, J., Lipton, S. A., Lloyd, N. K., Logothetis, D. E., Luo, Y., MacKinnon, R., Makriyannis, A., Malamud, D., Manning, J. M., Marian Orlowski, N., Matunis, M. J., Mclachlin, D. T., Merrifield, R. B., Merrifield, B., Merrifield, N. R., Miller, D. L., Miller, C. M., Minakhin, L., Mirza, U. A., Mirza, U., Molloy, K., Muesing, M. A., Muir, T., Muir, T. W., Müller, M., Myung, S., Nairn, N. A., Nairn, A. C., Nakanishi, K., Neubert, T. A., Niu, S., Nogoceke, E., Nui, S., Nussenzweig, M. C., Nussenzweig, R. S., O'donnell, M. E., Oakley, M. G., Oda, Y., Oelgeschlager, T., Orlowski, M., Padovan, J. C., Padovan, J., Peterson, C. L., Pochapsky, T. C., Prusiner, S. B., Qin, J., Raleigh, D. P., Ravetch, J. V., Rice, C. M., Riggs, A. F., Roeder, R. G., Romanelli, A., Rout, M. P., Sakmar, T. P., Sali, A., Sechi, S., Sehayek, E., Seibert, C., Sekedat, M., Severinov, N. K., Severinov, K. V., Shenk, T. E., Smith, A. B., Speigel, A., Spiegel, A. M., Stebbins, C. E., Steinman, R. M., Steller, H., Stoffel, M., Stuart, A., Tackett, A. J., Tam, J. P., Tang, N. H., Tarakhovsky, A., Tischer, E., Tjernberg, A., Tomasz, N. A., Trester, M., Ueberheide, B. M., Upmacis, R. K., Vallee, R. B., Varmus, H. E., Wang, Q., Wang, R., Wang, Z., Weiss, E., Wendel, H., Werner, M. H., Wlodawer, A., Woo, E., Woolford, J. L., Wu, X., Yanagisawa, K., Young, R., Yue, Z., Zhang, J. J., Zhang, J., Zhang, W., Zhao, Y., Zimniak, P., Buku, A., Chait, B. T., Goodman, S., Kappas, A., Lin Yao-zhong Lin, N., Marchal, G., Severinov, K., Tang, H. & Unson, C.

    12/1/843/31/12

    Project: Research project