Resolution of inflammation in healing myocardial infarcts

Project: Research project

Project Details

Description

NARRATIVE Transforming Growth Factor (TGF)- superfamily members play a critical role in repair, remodeling and fibrosis of the infarcted heart, signaling through intracellular effectors, the Smads and through non-Smad pathways. The current proposal will investigate cell- specific actions of Smad1 cascades in the infarcted heart. In vivo experiments using cell- specific knockout mice, in vitro loss- and gain-of-function studies and single cell RNAseq experiments will be performed to study Smad1-mediated actions on fibroblasts, macrophages, cardiomyocytes and pericytes, to dissect the molecular mechanisms responsible for Smad1 effects, and to explore the role of TGF- signaling responses in mediating subset-specific functions of immune and reparative cells.
StatusActive
Effective start/end date1/15/0812/31/22

Funding

  • National Heart, Lung, and Blood Institute: $504,048.00
  • National Heart, Lung, and Blood Institute: $487,298.00
  • National Heart, Lung, and Blood Institute: $397,460.00
  • National Heart, Lung, and Blood Institute: $709,378.00
  • National Heart, Lung, and Blood Institute: $373,500.00
  • National Heart, Lung, and Blood Institute: $345,375.00
  • National Heart, Lung, and Blood Institute: $345,375.00
  • National Heart, Lung, and Blood Institute: $417,500.00
  • National Heart, Lung, and Blood Institute: $308,427.00
  • National Heart, Lung, and Blood Institute: $345,375.00
  • National Heart, Lung, and Blood Institute: $207,138.00
  • National Heart, Lung, and Blood Institute: $280,160.00
  • National Heart, Lung, and Blood Institute: $102,810.00
  • National Heart, Lung, and Blood Institute: $409,150.00
  • National Heart, Lung, and Blood Institute: $369,765.00
  • National Heart, Lung, and Blood Institute: $487,298.00

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