Project Details
Description
NARRATIVE
Transforming Growth Factor (TGF)- superfamily members play a critical role in repair,
remodeling and fibrosis of the infarcted heart, signaling through intracellular effectors,
the Smads and through non-Smad pathways. The current proposal will investigate cell-
specific actions of Smad1 cascades in the infarcted heart. In vivo experiments using cell-
specific knockout mice, in vitro loss- and gain-of-function studies and single cell
RNAseq experiments will be performed to study Smad1-mediated actions on fibroblasts,
macrophages, cardiomyocytes and pericytes, to dissect the molecular mechanisms
responsible for Smad1 effects, and to explore the role of TGF- signaling responses in
mediating subset-specific functions of immune and reparative cells.
Status | Active |
---|---|
Effective start/end date | 1/15/08 → 12/31/22 |
Funding
- National Heart, Lung, and Blood Institute: $504,048.00
- National Heart, Lung, and Blood Institute: $487,298.00
- National Heart, Lung, and Blood Institute: $397,460.00
- National Heart, Lung, and Blood Institute: $709,378.00
- National Heart, Lung, and Blood Institute: $373,500.00
- National Heart, Lung, and Blood Institute: $345,375.00
- National Heart, Lung, and Blood Institute: $345,375.00
- National Heart, Lung, and Blood Institute: $417,500.00
- National Heart, Lung, and Blood Institute: $308,427.00
- National Heart, Lung, and Blood Institute: $345,375.00
- National Heart, Lung, and Blood Institute: $207,138.00
- National Heart, Lung, and Blood Institute: $280,160.00
- National Heart, Lung, and Blood Institute: $102,810.00
- National Heart, Lung, and Blood Institute: $409,150.00
- National Heart, Lung, and Blood Institute: $369,765.00
- National Heart, Lung, and Blood Institute: $487,298.00
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