Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer

Project: Research project

Project Details

Description

NARRATIVE Carbon ion radiotherapy (CIRT) is currently the world’s most advanced radiotherapeutic technique; compared with traditional photon radiotherapy, it has unique physical characteristics and biological advantages. It is better at protecting the normal tissue and organs surrounding the tumor and is more effective at killing tumor tissue and particularly tumor cells that can normally resist photon radiotherapy. While X-ray therapy using photons travel through our body, carbon ion is like a dart. It stops at a depth inside our body and releases all its energy in the form of a peak dose in the tumor. Since the track stops at a depth, the particle beam does not go through the body, thereby causing less harm to surrounding normal tissues. Since the particles cause DNA damage and the irradiated cells behave as if they are infected by a DNA virus and increase the body’s anti-viral defense system. We are looking into possible immune activating role of CIRT that possibly helps us fight cancer. We are going to look into the immunological consequences of CIRT for the treatment of pancreatic cancer, a devastating disease where we are losing our battle. Our goal is to determine the immunological effectiveness of CIRT compared to XRT (X rays) in mouse pancreatic cancer models for the treatment of both primary and metastatic cancer. If successful, this will allow us to bring a very sophisticated therapy for our cancer patients.
StatusActive
Effective start/end date1/14/2112/31/22

Funding

  • National Cancer Institute: $527,544.00
  • National Cancer Institute: $564,066.00

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