Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer

Project: Research project

Project Details

Description

NARRATIVE
Carbon ion radiotherapy (CIRT) is currently the world’s most advanced radiotherapeutic technique;
compared with traditional photon radiotherapy, it has unique physical characteristics and
biological advantages. It is better at protecting the normal tissue and organs surrounding the
tumor and is more effective at killing tumor tissue and particularly tumor cells that can normally
resist photon radiotherapy. While X-ray therapy using photons travel through our body, carbon
ion is like a dart. It stops at a depth inside our body and releases all its energy in the form of a
peak dose in the tumor. Since the track stops at a depth, the particle beam does not go through
the body, thereby causing less harm to surrounding normal tissues. Since the particles cause
DNA damage and the irradiated cells behave as if they are infected by a DNA virus and increase
the body’s anti-viral defense system. We are looking into possible immune activating role of CIRT
that possibly helps us fight cancer. We are going to look into the immunological consequences of
CIRT for the treatment of pancreatic cancer, a devastating disease where we are losing our battle.
Our goal is to determine the immunological effectiveness of CIRT compared to XRT (X rays) in
mouse pancreatic cancer models for the treatment of both primary and metastatic cancer. If
successful, this will allow us to bring a very sophisticated therapy for our cancer patients.
StatusActive
Effective start/end date1/14/2112/31/22

Funding

  • National Cancer Institute: $527,544.00
  • National Cancer Institute: $564,066.00

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