REGULATION OF HUMAN IGH GENE LOCUS BY 3 ENHANCERS

  • Birshtein, Barbara K. (PI)

Project: Research project

Project Details

Description

The investigator's group has surmounted some cloning barriers and has
succeeded in identifying two virtually identical enhancers, one located
approximately 10 kb 3' of each of the two human C alpha genes.
These enhancers contain a 191 bp segment of homology to the murine
enhancer 3'aE (Hst2). They wish to study the regulation of the human
C alpha associated enhancers, to further map these downstream
regions and assess them for additional enhancers which they predict to
be present, and to acquired variations that influence IgH gene
expression in normal, immunodeficient and malignant states.
StatusFinished
Effective start/end date9/15/978/31/03

Funding

  • National Institute of Allergy and Infectious Diseases: $167,240.00
  • National Institute of Allergy and Infectious Diseases
  • National Institute of Allergy and Infectious Diseases
  • National Institute of Allergy and Infectious Diseases
  • National Institute of Allergy and Infectious Diseases: $172,188.00

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