PRECLINICAL TESTING OF HUMAN GHRELIN AND GROWTH HORMONE FOR SEPSIS IN THE ELDLY

Project: Research project

Project Details

Description

DESCRIPTION (provided by applicant): The ultimate goal of our proposal is to develop a novel therapeutic approach that will save lives of aged septic patients. Sepsis is the most common cause of death in the non-cardiac intensive care units (ICU). It is particularly a serious problem in the geriatric population. The elderly (e 65 years of age) accounts for 12% of the US population but 65% of sepsis cases. Nearly 80% of septic deaths occur in elderly patients. Although this problem is increasingly recognized, current treatment options for aged septic patients are very limited. Ghrelin is an endogenous ligand for the growth hormone (GH) secretagogue receptor 1a (GHSR1a, i.e., ghrelin receptor). We have shown that administration of ghrelin inhibits inflammatoryresponses, attenuates organ injury, and reduces mortality in young septic animals. Ghrelin's beneficial effects are attributed to the activation of the vagus nerve through ghrelin receptors in the brain. We have also shown a greater production of pro

StatusFinished
Effective start/end date1/1/148/31/19

Funding

  • National Institute on Aging: $224,890.00
  • National Institute on Aging: $486,925.00
  • National Institute on Aging: $540,425.00
  • National Institute on Aging: $540,425.00

ASJC

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology
  • Pharmacology (medical)
  • Medicine(all)
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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