Models for DNA repair and cell cycle control variants

Project: Research project

Project Details

Description

DESCRIPTION (Taken from the Applicant's Abstract)
Currently, a wealth of transgenic and mutant mouse models are being generated
for studying the role of defective DNA repair and cell cycle control in
environmentally induced human diseases, such as cancer. One of the
fundamental problems in the development and utilization of such models is
their short-term focus. Very few, if any, of the current models are designed
to study human disease and functional decline during the aging process. This
is in spite of the demonstrated relationship between adverse effects related
to aging and long-term exposure to environmental and endogenous DNA damaging
agents. Thus, there is a need to focus mouse model development and derivation
for the specific purpose of studying DNA repair in relation to environmental
exposures in the context of the aging process. The team of investigators
involved in this application wishes to become a component of the Comparative
Mouse Genomics Centers Consortium. They will bring their expertise in DNA
repair, cell cycle control, mouse genetic modeling and genetic toxicology, and
the generation of molecular databases, with a unique focus on aging and its
related intrinsic and environmentally induced disease sequelae. The mouse
models proposed to be derived are mimics of human p53, base excision repair,
and nucleotide excision repair gene variants. The investigators propose to
use their knowledge and technology base in life span studies, exposure
studies, molecular end point studies, and molecular effect databases to
characterize and validate these variants.
StatusFinished
Effective start/end date1/1/063/31/08

Funding

  • National Institute of Environmental Health Sciences: $613,571.00

ASJC

  • Genetics
  • Molecular Biology

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