METABOLISM OF THE MALARIA PARASITE

  • Pollack, Simeon (PI)

Project: Research project

Project Details

Description

The Principal Investigator and associates have demonstrated that Plasmodium
falciparum, growing in vitro in a Trager-Jensen culture system, is
sensitive to exceedingly small concentrations of desferrioxamine (DF), a
specific iron chelating agent, despite the large quantity of iron available
to the intraerythrocytic malarial parasite in the form of hemoglobin. Thus
the mechanism of iron acquisition by the malaris parasite is delicate and
readily disrupted. That mechanism is of intrinsic biologic interest, but
equally important, its elucidation may facilitate a new approach to
therapy. The continual emergence of drug resistant malaria throughout the
world makes the availability of new therapeutic approaches an important
practical concern. Our specific aims are to study iron uptake by P. falciparum from
transferrin, hemoglobin and ferritin and to study the distribution of that
iron in the parasitizedd red call.
StatusFinished
Effective start/end date9/30/858/31/89

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)