Metabolic control in vascular remodeling

Project Narrative Cardiovascular disease – especially vascular obstruction – is the leading cause of death and disability worldwide. In this project, we will study genetically modified mice, cells in culture, and pharmacological effects to increase understanding of mitochondria-mediated regulation of vascular wall cell functions during artery formation in embryogenesis and in mouse models of vascular disease in adulthood. The goal of this research is to identify novel points of susceptibility for pharmacological intervention, which in the long term, may enhance health, increase life span, and reduce disability due to vascular disease.