Mechanisms Underlying the HIV-HSV-2 Syndemic

Project: Research project

Project Details

Description

Epidemiological studies consistently demonstrate that HSV-2 adversely impacts HIV. Defining the underlying mechanisms will lead to the development of new strategies for HIV eradication. We propose to test the hypothesis that HSV-2 promotes changes in peripheral blood CD4+ T cells that facilitate HIV reactivation and to identify pathways and molecules that could be targeted to block HIV reactivation in response to HSV-2 or conversely, enhance latency reversal as part of “shock and kill” HIV eradication strategies.
StatusActive
Effective start/end date12/5/1711/30/22

Funding

  • National Institute of Allergy and Infectious Diseases: $483,050.00
  • National Institute of Allergy and Infectious Diseases: $488,089.00
  • National Institute of Allergy and Infectious Diseases: $494,568.00
  • National Institute of Allergy and Infectious Diseases: $518,436.00
  • National Institute of Allergy and Infectious Diseases: $509,551.00
  • National Institute of Allergy and Infectious Diseases: $2,743.00

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