LUNG CANCER SUSCEPTIBILITY MARKERS IN SURROGATE TISSUES

Project: Research project

Project Details

Description

The candidate, Simon D. Spivack, MD, MPH, is an academic
pulmonary physician with demonstrated interest and background
in experimental and clinical environmentally-induced lung
disease, molecular biology, toxicology and epidemiology. the
candidate views the K08 Mentored Clinical Scientist
Development Award as facilitating his immediate career goal of
developing into an independent investigator in the field of
molecular epidemiology as it relates to lung cancer. Long-term
career goals are to address major issues related to the
environment-human lung interface, combining molecular
genetic, clinical and epidemiologic perspectives, in the context
of an academic medicine and public health career.

the environment for the K08 proposal includes the Laboratory
of Human Toxicology & Molecular Epidemiology, Wadsworth
Center of the New York State Department of Health, the
supporting departments of epidemiology, biostatistics,
molecular genetics, biological imaging, the SUNY School of
Public Health, and the clinical and pathological resources of the
Albany Medical College and Veterans Administration
Hospitals.

The research project is aimed at defining individual genetic
susceptibility factors that confer risk for lung cancer, in a
manner applicable to broad-based lung cancer screening
programs. The phase I and phase II enzymes responsible for
activation of tobacco-smoke constituents to carcinogens, and
their coordinate deactivation, display polymorphism across
individuals, and are reasonable candidate biomarkers associated
with individual lung cancer susceptibility. First, the utility of
easily-accessed surrogate tissues as substitutes for target lung
tissue will be examined as they reflect molecular events in lung
carcinogenesis. Procarcinogen metabolizing polymorphisms
and biomarkers of DNA damage will be assessed in human
lung, nasal epithelium and peripheral lymphocytes from the
same individual. Second, biomarkers measured in surrogate
tissue will be validated as lung cancer susceptibility markers by
correlation with the presence or absence of lung cancer in an
individual, in a case-control design. Therefore, this project
will valuate the feasibility of molecular screening in lung
cancer.
StatusFinished
Effective start/end date7/25/976/30/98

Funding

  • National Institute of Environmental Health Sciences

ASJC

  • Molecular Medicine
  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research
  • Epidemiology

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