Project Details
Description
NARRATIVE/ PUBLIC HEALTH RELEVANCE
There is increased awareness that non-allergic asthma exists in children, and obesity-related asthma is the
most commonly reported form of pediatric non-allergic asthma. Obese asthmatic children are poorly
responsive to existing asthma medications but there is no targeted therapy for non-allergic asthma since its
underlying immune pathways are not well understood. Having identified the CDC42 pathway as a novel
pathway associated with pediatric non-allergic obese asthma, we will investigate the cell type in which it is
upregulated and identify proteins in signaling pathways downstream of CDC42 as potential targets for
therapeutic intervention for obesity-related asthma.
Status | Active |
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Effective start/end date | 2/1/19 → 1/31/23 |
Funding
- National Heart, Lung, and Blood Institute: $450,783.00
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