Intraventricular Hemorrhage Disrupts the Blood Brain Barrier in Premature Infants

Project Narrative The research is relevant to public health because discovery of mechanisms by which intraventricular hemorrhage (IVH) contributes to cerebral palsy and hydrocephalus will lead to interventions to prevent these disorders. In the proposed study, we will evaluate lipid signaling and target their receptors to accomplish recovery in neurological function and prevent two devastating disorders--cerebral palsy and hydrocephalus--in the survivors of IVH.