Project Details
Description
The advent of continuous flow mechanical circulatory support (CF MCS) devices for patients
with severe heart failure has led to marked improvements in survival; however, pump operation
remains fraught with adverse thrombotic events such as stroke. Despite alterations in device
design, the rate of disabling stroke remains elevated and the hematologic mechanisms behind
these devastating adverse events remain unknown. This proposal will investigate if during CF
MCS hemolysis creates a pro-thrombotic state through increasing platelet activation and if
pharmacologic potentiation of nitric oxide signaling by an oral phosphodiesterase-5 inhibitor
sildenafil lowers platelet activity. Elucidating mechanisms of hemolysis induced thrombosis may
inform targeted anti-thrombotic strategies for prevention of end organ damage.
Status | Active |
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Effective start/end date | 1/15/19 → 12/31/22 |
Funding
- National Heart, Lung, and Blood Institute: $194,805.00
- National Heart, Lung, and Blood Institute: $165,240.00
- National Heart, Lung, and Blood Institute: $165,240.00
- National Heart, Lung, and Blood Institute: $165,240.00
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