Epilepsy and Electrical Stimulation of the STN

  • Lado, Fred A. (PI)

Project: Research project

Project Details


DESCRIPTION (provided by applicant): This application is for a Mentored
Clinical Scientist Development Award (K08) for Fred Lado, MD PhD. Dr. Lado
obtained clinical training in neurology at the Cornell University Medical
College and subsequently completed a fellowship in Clinical Neurophysiologywith emphasis in EEG and Epilepsy at the Albert Einstein College of Medicine. His
current faculty appointment in the Department of Neurology at the Albert
Einstein College of Medicine began in 1999. He previously received a PhD for
his investigation of human subjects using magnetoencepahalography, but he is
currently learning in vivo experimental methods using animals, as these are
best suited to his longterm career goals. His goals are to study subcortical
structures that regulate and propagate seizure activity, and to develop
therapies targeting these regions in order to control human epilepsy. The
Albert Einstein College of Medicine and the Montefiore Medical Center, the main
teaching hospital of the College, offer broad strengths in basic neuroscience
and clinical epileptology. Laboratory space, equipment, office space and access
to established scientists across multiple disciplines are readily available.
Opportunities for didactic instruction are also available through the medical
college and through specialized summer courses. The environment and support
available to the candidate are ideally suited to promoting and fostering Dr.
Lado's longterm professional goals.

Dr. Lado proposes to investigate the anticonvulsant effects of electrical
stimulation of the subthalamic nucleus. The goals of these investigations are
fourfold. (1) To investigate a novel treatment of seizures of adults using deep
brain electrical stimulation of the subthalamic nucleus (STN). (2) To
investigate the mechanisms of anticonvulsant action of STN stimulation and
further development of our basic understanding of intrinsic anticonvulsant
networks in the brain. (3) To determine whether anticonvulsant deep brain
stimulation produces detrimental effects. And (4), to determine whether deep
brain stimulation at the STN has an antiepileptogenic or neuroprotective
effect. In the course of the proposed work, Dr. Lado will learn methods of
intracranial injection, induction of chemical and electrical seizures, in vivo
electrophysiology to record single unit and population activity, 2deoxyglucose
autoradiography to map metabolic activation, neuroanatomical methods to detect
synaptic reorganization and neuronal injury, and biostatistics.

The proposed studies are designed to translate the insights and results
obtained from animal research into improved treatments of human epilepsy.
Moreover, the work described in this proposal will provide the investigator
with an opportunity to acquire the necessary intellectual and technical skills
be an independent investigator in translational i epilepsy research.
Effective start/end date8/1/017/31/06


  • National Institute of Neurological Disorders and Stroke: $131,490.00
  • National Institute of Neurological Disorders and Stroke: $131,490.00


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